TERBINAFORCE PLUS NF CREAM

🧴🛡️💊 Ornidazole + Clobetasol + Ofloxacin + Terbinafine Cream: Broad-Spectrum Solution for Mixed Skin Infections

Overview:

This powerful combination cream containing Ornidazole, Clobetasol, Ofloxacin, and Terbinafine is a topical medication designed to treat mixed skin infections involving fungal, bacterial, protozoal, and inflammatory components. It is commonly prescribed for infected fungal infections, eczema with secondary infections, seborrheic dermatitis, and superficial skin lesions that show signs of both infection and inflammation.

🧪 Composition and Their Roles:

1. Ornidazole (Antiprotozoal & Antibacterial):

   • A nitroimidazole derivative that acts against anaerobic bacteria and protozoa.

   • Disrupts DNA synthesis, leading to microbial death.

   • Helps treat secondary anaerobic infections on the skin.

2. Clobetasol Propionate (Corticosteroid):

   • A potent topical steroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties.

   • Reduces redness, swelling, itching, and other symptoms of skin inflammation.

   • Provides fast symptomatic relief, but must be used cautiously to avoid side effects.

3. Ofloxacin (Fluoroquinolone Antibiotic):

   • Broad-spectrum antibacterial agent active against gram-positive and gram-negative bacteria.

   • Inhibits DNA gyrase, essential for bacterial replication.

   • Effective against superficial bacterial infections or contamination.

4. Terbinafine (Antifungal):

   • Belongs to the allylamine class of antifungals.

   • Inhibits squalene epoxidase, essential for fungal cell membrane formation.

   • Kills fungi like dermatophytes, yeast, and molds.

📌 Indications and Uses:

This combination cream is typically prescribed for:

• Tinea infections (e.g., Tinea corporis, Tinea cruris) with secondary infection

• Intertrigo with signs of infection

• Infected eczema or dermatitis

• Fungal infections with bacterial superinfection

• Mixed skin infections caused by fungi, bacteria, or protozoa

• Seborrheic dermatitis, if infected or inflamed

💡 How to Use:

• Clean and dry the affected area before application.

• Apply a thin layer once or twice daily as directed by a healthcare professional.

• Wash hands after use unless treating hand-related infection.

• Avoid contact with eyes, mouth, or broken skin.

⚠️ Precautions and Warnings:

• Clobetasol should not be used for prolonged periods—may cause skin thinning, stretch marks, or local immunosuppression.

• Not suitable for long-term use or application on large body surfaces.

• Avoid use in children under 12 years unless prescribed.

• Do not apply under occlusive dressings unless advised.

• Pregnancy and lactation: Use only under medical supervision.

🤒 Possible Side Effects:

• Local irritation, burning, or redness

• Skin thinning or depigmentation (with prolonged steroid use)

• Superinfection or resistance (if overused)

• Allergic contact dermatitis (rare)

🔄 Storage:

• Store in a cool, dry place (below 25°C)

• Keep away from direct sunlight and heat

• Keep out of reach of children

📝 Conclusion:

The Ornidazole + Clobetasol + Ofloxacin + Terbinafine cream offers a comprehensive approach to treating complex skin infections involving multiple pathogens and inflammatory symptoms. With proper medical guidance, this formulation ensures quick relief, infection control, and restoration of skin health. However, it should be used cautiously and only for short durations to prevent side effects, especially those related to steroids.