THIABION TABLET

🧠⚡💊 Thiamine Hydrochloride 100mg Tablet: Essential Vitamin B1 for Nerve, Brain & Energy Health

Thiamine Hydrochloride 100mg tablet is a high-potency supplement form of vitamin B1 (thiamine)—a water-soluble B-complex vitamin essential for carbohydrate metabolism, nerve function, and muscle activity. It plays a vital role in converting food into energy and maintaining the health of the nervous system, heart, and brain. Thiamine deficiency can lead to serious disorders like beriberi, Wernicke’s encephalopathy, and peripheral neuropathy, especially in individuals with chronic illnesses or poor nutritional intake.

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🔬 Mechanism of Action

Thiamine, after being absorbed, is converted in the body to its active form—thiamine pyrophosphate (TPP). TPP functions as a coenzyme in multiple metabolic processes, particularly in:

• Krebs cycle (citric acid cycle): helping in ATP (energy) production

• Decarboxylation of keto acids and oxidative metabolism of carbohydrates

• Supporting the synthesis of neurotransmitters (e.g., acetylcholine)

• Facilitating nerve impulse conduction

A deficiency impairs these pathways, resulting in energy depletion, oxidative stress, and nerve damage.

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📌 Indications and Uses

Thiamine 100mg tablets are indicated in the treatment and prevention of:

• Thiamine deficiency due to:

  • Malnutrition

  • Chronic alcoholism

  • Prolonged vomiting or fasting

  • Post-surgery recovery (especially bariatric surgery)

• Beriberi (dry and wet forms)

• Wernicke’s encephalopathy (a neurological emergency)

• Peripheral neuropathy

• Alcohol-related neurological damage

• Supportive therapy in cardiac conditions related to deficiency

• Supplementation in high-risk patients (e.g., diabetics, elderly, cancer patients, HIV/AIDS)

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💊 Dosage and Administration

• Standard therapeutic dose: 1–2 tablets daily or as prescribed

• For acute deficiency or neurological symptoms, higher or injectable doses may be used

• Should be taken after food, with water

• Long-term supplementation may be advised in high-risk groups under medical supervision

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⚠️ Precautions and Warnings

• Generally safe and well-tolerated

• Avoid in known hypersensitivity to thiamine or any excipients

• No significant toxicity reported even in higher doses due to its water-soluble nature

• Use with caution in:

  • Pregnancy or breastfeeding (safe at recommended doses)

  • Patients with renal impairment, if long-term high doses are used (rare risk of accumulation of inactive metabolites)

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🤒 Side Effects

Thiamine rarely causes side effects. When they do occur, they may include:

Mild:

• Nausea or stomach upset

• Headache

• Allergic skin reactions (rash, itching)

Rare/Severe:

• Hypersensitivity or anaphylaxis (mostly with IV formulations, not oral tablets)

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🔄 Drug Interactions

• May reduce the effects of loop diuretics (e.g., furosemide) as they increase thiamine excretion

• Alcohol impairs thiamine absorption and metabolism—supplementation is essential in alcoholics

• No major interactions with most commonly used medications

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🧊 Storage Instructions

• Store in a cool, dry place (15–25°C)

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

Thiamine Hydrochloride 100mg tablet is a safe and effective supplement that supports brain function, nerve health, and energy metabolism. It plays a crucial role in the treatment of deficiency-related neurological and cardiovascular conditions, especially in vulnerable groups like alcoholics, elderly, and malnourished patients. Regular supplementation, when medically indicated, helps prevent irreversible nerve damage and enhances overall metabolic function.