TOLOL H 50 TABLET

💊METOPROLOL SUCCINATE 50MG + HYDROCHLOROTHIAZIDE 12.5MG – POWERFUL DUO FOR BLOOD PRESSURE CONTROL

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✅ OVERVIEW:

Metoprolol Succinate 50mg + Hydrochlorothiazide 12.5mg is a fixed-dose combination medication used to manage high blood pressure (hypertension) effectively. It combines:

• Metoprolol Succinate (50mg) – a cardioselective beta-blocker that reduces heart rate and cardiac output.

• Hydrochlorothiazide (12.5mg) – a thiazide diuretic that helps the body eliminate excess salt and water.

Together, they provide a synergistic effect in lowering blood pressure and reducing the risk of cardiovascular complications such as stroke, heart attack, and heart failure.

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🩺 USES:

1. Essential Hypertension:
   Especially useful in patients not adequately controlled by a single agent.

2. Cardiovascular Event Prevention:
   Reduces the risk of myocardial infarction and stroke in hypertensive patients.

3. Management of Volume Overload:
   Hydrochlorothiazide helps reduce mild fluid retention, enhancing blood pressure control.

4. Adjunct in Heart Failure (select patients):
   Helps manage heart failure symptoms when combined with other drugs.

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🧪 INGREDIENTS:

• Active Ingredients:

  • Metoprolol Succinate (Extended-Release) – 50mg

  • Hydrochlorothiazide – 12.5mg

• Inactive Ingredients (may vary by manufacturer):

  • Microcrystalline cellulose

  • Hypromellose

  • Magnesium stearate

  • Titanium dioxide

  • Sodium stearyl fumarate

  • Polyethylene glycol

  • Colorants and film-coating agents

This tablet provides once-daily dosing due to the extended-release formulation of Metoprolol.

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⚠️ SIDE EFFECTS:

Common:

• Fatigue or dizziness

• Low blood pressure (hypotension)

• Slow heart rate (bradycardia)

• Frequent urination

• Electrolyte disturbances (low potassium or sodium)

Less Common but Serious:

• Irregular heartbeat or palpitations

• Severe hypotension or dehydration

• Mood changes, including depression

• Allergic reactions (rash, swelling)

• Increased blood sugar or uric acid levels

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⚠️ PRECAUTIONS:

• Diabetes: Monitor blood sugar levels; beta-blockers can mask hypoglycemia.

• Renal Function: Regular monitoring advised due to the risk of electrolyte imbalance and dehydration.

• Liver Dysfunction: May require dose adjustments.

• Gout: Hydrochlorothiazide may elevate uric acid levels.

• Asthma/COPD: Use with caution, as beta-blockers may worsen bronchospasm.

• Pregnancy & Breastfeeding: Use only if prescribed; potential risk to fetus or infant.

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🕒 DOSAGE & ADMINISTRATION:

• Once daily, preferably in the morning to minimize nighttime urination.

• Take with or without food.

• Do not crush or split the extended-release tablet.

• Ensure adequate fluid intake, especially in hot weather or during physical activity.

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🔁 STORAGE:

• Store at 20–25°C (68–77°F) in a dry place.

• Keep in original container, away from light and moisture.

• Keep out of reach of children.

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🩺 SUMMARY:

Metoprolol Succinate 50mg + Hydrochlorothiazide 12.5mg is a clinically proven dual therapy for high blood pressure. It combines the benefits of heart rate control with effective diuresis, enhancing treatment outcomes for patients with moderate hypertension or cardiovascular risk. Regular follow-up and monitoring ensure safe and optimal use.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.