TOPRA D EYE/EAR DROP

👁️💧🛡️ Dexamethasone 0.1% + Tobramycin 0.3% Eye Drops: Dual-Action Formula for Eye Inflammation & Infection

Dexamethasone 0.1% + Tobramycin 0.3% is a combination ophthalmic solution used to treat inflammatory eye conditions associated with or at risk of bacterial infection. This fixed-dose formulation merges the potent anti-inflammatory effects of dexamethasone, a corticosteroid, with the broad-spectrum antibacterial action of tobramycin, an aminoglycoside antibiotic. Together, they help reduce eye redness, swelling, pain, and bacterial contamination, offering comprehensive relief in post-operative care, conjunctivitis, keratitis, and other inflammatory conditions of the eye.

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🔬 Mechanism of Action

🔹 Dexamethasone 0.1% (Corticosteroid)

• Inhibits the production of inflammatory mediators (prostaglandins, leukotrienes)

• Suppresses immune cell infiltration and cytokine release

• Reduces swelling, redness, and discomfort in the eye

🔹 Tobramycin 0.3% (Aminoglycoside Antibiotic)

• Binds to bacterial 30S ribosomal subunit, disrupting protein synthesis

• Provides effective coverage against Gram-negative and some Gram-positive bacteria

• Helps prevent or treat secondary bacterial infections in inflamed ocular tissues

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📌 Indications and Uses

This combination eye drop is indicated for:

• Post-operative inflammation following cataract or other eye surgeries

• Bacterial conjunctivitis with inflammation

• Blepharitis (eyelid inflammation)

• Keratitis (corneal inflammation)

• Uveitis

• Corneal injury due to chemicals, radiation, or burns (if risk of infection exists)

• Ocular trauma where both infection and inflammation are concerns

It is commonly prescribed after eye surgery to control pain and swelling and prevent bacterial infection.

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💧 Dosage and Administration

• Usual adult dose: 1–2 drops in the affected eye(s) every 4–6 hours

• In severe cases: dosage may be increased to every 1–2 hours, then tapered

• Duration: Usually 5–14 days, or as advised by the ophthalmologist

• Shake well before use

• Do not touch the dropper tip to avoid contamination

Contact lenses should be removed before use and reinserted after at least 15 minutes.

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⚠️ Precautions and Warnings

• Prolonged use may cause:

  • Increased intraocular pressure (IOP)

  • Glaucoma

  • Cataract formation

  • Secondary fungal infections

• Use with caution in:

  • Viral eye infections (e.g., herpes simplex)

  • Corneal thinning

• Monitor IOP regularly, especially with long-term use

• Not recommended in pediatric patients without specialist advice

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🤒 Side Effects

Common:

• Temporary eye irritation or burning

• Blurred vision immediately after use

• Dryness or redness

Less common/serious:

• Increased eye pressure

• Allergic reaction

• Corneal thinning or ulceration

• Superinfections (fungal/viral) with prolonged use

Stop use and seek medical help if vision changes, severe pain, or signs of allergic reaction appear.

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🔄 Drug Interactions

• Avoid concurrent use with other steroid-containing eye drops unless prescribed

• Increased risk of eye damage with long-term NSAID use

• Inform your doctor of any ocular medications being used concurrently

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🧊 Storage Instructions

• Store at 2°C to 25°C (do not freeze)

• Protect from light and contamination

• Use within 1 month after opening

• Keep out of reach of children

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📝 Conclusion

Dexamethasone 0.1% + Tobramycin 0.3% eye drops offer a powerful dual-action therapy for managing eye inflammation with bacterial risk. Whether used after surgery or in inflammatory eye conditions, it provides rapid relief while protecting against infection. With proper usage and monitoring, it supports healing, comfort, and clearer vision during recovery.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.