TRIMEZEN MR TABLET

❤️⚙️💊 Trimetazidine 35mg Tablet: Cellular Cardioprotection for Stable Angina Relief

Trimetazidine 35mg is a metabolic antianginal agent used primarily in the management of stable angina pectoris (chest pain due to reduced blood flow to the heart). Unlike traditional antianginal medications that primarily affect blood pressure or heart rate, Trimetazidine works at the cellular level to improve energy efficiency in heart muscle cells, especially under conditions of oxygen deprivation (ischemia).

This unique mechanism helps prevent angina attacks, reduce fatigue, and improve exercise tolerance without affecting hemodynamic parameters like heart rate or blood pressure—making it suitable for patients who may not tolerate conventional therapies.

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🔬 Mechanism of Action

Trimetazidine selectively inhibits the enzyme 3-ketoacyl-CoA thiolase (LC 3-KAT) in the fatty acid oxidation pathway within mitochondria. This:

• Promotes a switch from fatty acid to glucose oxidation

• Enhances ATP production under ischemic conditions (low oxygen)

• Reduces intracellular acidosis and calcium overload

• Improves cardiac cell survival and function during ischemic stress

This cellular protection reduces the frequency and severity of angina attacks, especially during physical or emotional stress.

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📌 Indications and Uses

Trimetazidine 35mg is indicated for:

• Stable angina pectoris (as add-on therapy to standard antianginal agents)

• Adjunctive treatment in ischemic heart disease where conventional drugs are inadequate or poorly tolerated

• Management of tinnitus and vertigo (less commonly, and off-label)

• Improving exercise tolerance and reducing angina symptoms in patients with chronic coronary artery disease (CAD)

It is not recommended for use in acute angina or as monotherapy for ischemic conditions.

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💊 Dosage and Administration

• Recommended dose: 35mg twice daily, preferably morning and evening with meals

• Swallow whole, do not crush or chew

• Dose adjustments may be required in patients with moderate renal impairment

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⚠️ Precautions and Warnings

• Not for acute coronary syndrome or unstable angina

• Avoid use in:

  • Severe renal impairment (creatinine clearance <30 mL/min)

  • Parkinson’s disease or movement disorders

  • Patients with restless leg syndrome or other extrapyramidal symptoms

• Use with caution in elderly patients—monitor for neurological side effects

Trimetazidine is not a substitute for revascularization procedures like angioplasty or bypass surgery.

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🤒 Side Effects

Common:

• Nausea

• Vomiting

• Stomach discomfort

• Headache

• Skin rash

Rare but serious:

• Extrapyramidal symptoms: tremors, rigidity, gait disturbance (Parkinsonism-like)

• Sleep disturbances

• Allergic reactions

Discontinue use immediately if any movement disorders or allergic reactions appear.

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🔄 Drug Interactions

• Trimetazidine has minimal known drug interactions

• Can be safely used with beta-blockers, nitrates, calcium channel blockers, antiplatelets, and statins

• Monitor renal function when used with nephrotoxic drugs

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🧊 Storage Instructions

• Store at room temperature (15–25°C)

• Keep in a dry, cool place, away from moisture and direct sunlight

• Keep out of reach of children

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📝 Conclusion

Trimetazidine 35mg tablet offers a novel, cellular-level approach to managing stable angina by enhancing heart muscle energy efficiency without altering heart rate or blood pressure. Its favorable safety profile, when used appropriately, makes it an excellent add-on therapy in long-term cardiovascular care—especially for patients with chronic ischemic symptoms who require symptom control without hemodynamic effects.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.