TRIODAY TABLET

🧬💊🌍 Lamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg Tablet: Triple Power for HIV Treatment

Lamivudine + Tenofovir Disoproxil Fumarate + Efavirenz is a fixed-dose antiretroviral combination therapy used in the treatment of HIV-1 infection. This once-daily tablet combines three powerful drugs to suppress the virus, improve immune function, and reduce the risk of HIV transmission. Each component plays a unique role in disrupting the HIV life cycle, making this combination a cornerstone in first-line antiretroviral therapy (ART), especially in resource-limited settings.

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🔬 Mechanism of Action

This combination includes:

• Lamivudine (300mg) – a nucleoside reverse transcriptase inhibitor (NRTI)

• Tenofovir disoproxil fumarate (300mg) – a nucleotide reverse transcriptase inhibitor (NtRTI)

• Efavirenz (600mg) – a non-nucleoside reverse transcriptase inhibitor (NNRTI)

Together, they inhibit the reverse transcriptase enzyme, preventing the conversion of viral RNA into DNA, which is crucial for HIV replication. This halts the virus’s ability to reproduce and infect new cells.

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📌 Indications and Uses

This fixed-dose combination is indicated for:

• Treatment of HIV-1 infection in adults and adolescents weighing ≥35 kg

• Used as part of highly active antiretroviral therapy (HAART)

• Helps in:

  • Lowering viral load

  • Increasing CD4+ cell counts

  • Delaying HIV progression to AIDS

  • Reducing the risk of HIV transmission (including mother-to-child)

It is not a cure for HIV, but enables people living with HIV to lead longer, healthier lives.

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💊 Dosage and Administration

• Recommended dose: 1 tablet once daily, preferably on an empty stomach at bedtime to reduce side effects like dizziness

• Must be taken regularly, at the same time daily, for best results

• Do not skip doses, as this increases the risk of resistance

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⚠️ Precautions and Warnings

• Hepatitis B: All three drugs are active against HBV; discontinuation can cause flare-ups in co-infected patients

• Monitor for:

  • Liver toxicity

  • Kidney function (especially with Tenofovir)

  • Mental health side effects (Efavirenz-related)

• Not recommended in severe renal impairment

• Use with caution during pregnancy and breastfeeding (consult a physician)

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🤒 Side Effects

Common:

• Dizziness, insomnia, vivid dreams (Efavirenz)

• Headache

• Fatigue

• Rash

• Diarrhea or nausea

Serious:

• Lactic acidosis

• Hepatotoxicity

• Renal toxicity

• Depression, anxiety, suicidal thoughts (especially with Efavirenz)

• Hypersensitivity reactions

Seek medical help for severe rash, yellowing of eyes/skin, confusion, or persistent vomiting.

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🔄 Drug Interactions

• Efavirenz may interact with:

  • Antifungals (e.g., ketoconazole)

  • Anti-seizure drugs

  • St. John’s Wort (avoid)

  • Oral contraceptives (may reduce effectiveness)

• Always inform the doctor about all medications and supplements

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🧊 Storage Instructions

• Store below 30°C, away from moisture and heat

• Keep in original packaging

• Keep out of reach of children

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📝 Conclusion

The Lamivudine + Tenofovir + Efavirenz 3-in-1 tablet offers a convenient, effective once-daily therapy for managing HIV-1 infection. Its synergistic triple-action approach helps suppress the virus, strengthen immunity, and improve quality of life for people living with HIV. Proper adherence, regular monitoring, and medical follow-ups are essential to maximize benefits and minimize side effects.

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Always follow your doctor’s advice, dosage instructions, and never self-medicate.