UDAPA GOLD 2 10/2/500 TABLET

Dapagliflozin + Glimepiride + Metformin: A Triple-Action Diabetes Medication

This fixed-dose combination of Dapagliflozin (10mg), Glimepiride (2mg), and Metformin (500mg) is prescribed for the treatment of Type 2 Diabetes Mellitus (T2DM). It is designed for patients whose blood sugar levels are not adequately controlled by monotherapy or dual therapy, along with diet and exercise. This combination targets different mechanisms of glucose regulation to provide better glycemic control.

Ingredients and Mechanism of Action

1. Dapagliflozin (10 mg)

• Class: SGLT2 inhibitor

• Function: Reduces blood sugar by preventing glucose reabsorption in the kidneys, leading to increased glucose excretion in the urine.

• Benefit: Aids in weight loss and lowers blood pressure.

2. Glimepiride (2 mg)

• Class: Sulfonylurea

• Function: Stimulates insulin secretion from pancreatic beta cells.

• Benefit: Rapidly reduces blood glucose levels post-meals.

3. Metformin (500 mg)

• Class: Biguanide

• Function: Decreases hepatic glucose production and improves insulin sensitivity.

• Benefit: Does not cause weight gain and has cardiovascular benefits.

Together, these three agents work synergistically to provide comprehensive glycemic control by reducing glucose production, increasing insulin secretion, and enhancing glucose elimination.

How to Use

• Dosage: As prescribed by your physician, usually once daily with food, typically in the morning.

• Administration: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

• Lifestyle: Continue following a diabetes-friendly diet and exercise routine for optimal results.

Consistency in timing and dosage is essential to maintain stable blood sugar levels.

Possible Side Effects

Like all medications, this combination may cause side effects. These may include:

Common Side Effects:

• Metformin: Nausea, diarrhea, metallic taste

• Glimepiride: Dizziness, weight gain, hypoglycemia (low blood sugar)

• Dapagliflozin: Increased urination, genital yeast infections, urinary tract infections

Serious Side Effects:

• Lactic acidosis (Metformin): A rare but serious condition with symptoms like rapid breathing, muscle pain, and abdominal discomfort.

• Ketoacidosis (Dapagliflozin): A rare complication even with normal blood sugar levels. Watch for nausea, vomiting, and confusion.

• Severe hypoglycemia (Glimepiride): Symptoms include sweating, trembling, confusion, and blurred vision.

Seek immediate medical attention if serious side effects occur.

Precautions and Warnings

• Not suitable for Type 1 diabetes or diabetic ketoacidosis.

• Use with caution in patients with kidney or liver impairment.

• Avoid alcohol as it increases the risk of lactic acidosis.

• Inform your doctor about all other medications to prevent drug interactions.

Conclusion

Dapagliflozin + Glimepiride + Metformin offers a comprehensive, triple-mechanism approach to managing Type 2 diabetes. It helps lower blood sugar effectively while offering additional benefits like weight reduction and improved insulin sensitivity. However, due to potential side effects and drug interactions, it must be used strictly under medical supervision.

Always follow your doctor’s guidance and maintain regular follow-up appointments to monitor your progress and adjust the treatment as needed.