UPNURON D 75/30 CAPSULE

🧠🔥💊 Duloxetine 30mg + Pregabalin 75mg Tablet: Dual-Action Relief for Nerve Pain, Anxiety & Fibromyalgia

Duloxetine 30mg + Pregabalin 75mg is a combination medication that offers synergistic relief from neuropathic pain, generalized anxiety disorder (GAD), fibromyalgia, and chronic musculoskeletal pain. By combining the central nervous system (CNS) effects of two powerful agents, this formulation is particularly effective in patients suffering from nerve damage-related pain and emotional distress.

This fixed-dose combination provides a multi-targeted approach to treating both the sensory (pain) and emotional (mood/anxiety) components of chronic pain syndromes.

🔬 Mechanism of Action

🔹 Duloxetine 30mg – Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)

• Inhibits reuptake of serotonin and norepinephrine in the brain

• Enhances pain inhibitory pathways in the spinal cord

• Offers antidepressant, anti-anxiety, and analgesic effects

• Reduces the intensity of chronic pain by modifying CNS perception

🔹 Pregabalin 75mg – Alpha-2-Delta Ligand / Anticonvulsant

• Binds to voltage-gated calcium channels in the CNS

• Reduces the release of excitatory neurotransmitters like glutamate, substance P, and norepinephrine

• Leads to reduced nerve hyperexcitability and neuropathic pain relief

• Also provides anti-anxiety and anti-convulsant effects

Together, they stabilize nerve activity, reduce pain perception, and help restore mental well-being.

📌 Indications and Uses

This combination is highly effective for:

• Diabetic Peripheral Neuropathy

• Postherpetic Neuralgia

• Fibromyalgia

• Chronic lower back pain with a neuropathic component

• Generalized Anxiety Disorder (GAD)

• Neuropathic pain of various causes

• Cancer-related nerve pain (in some cases)

It may be prescribed for patients unresponsive to monotherapy with either agent.

💊 Dosage and Administration

• Typically taken once or twice daily, based on individual patient response

• Should be taken with or without food

• Dose adjustments may be required in renal impairment

Do not discontinue abruptly; always taper down to avoid withdrawal symptoms.

⚠️ Precautions and Warnings

• Avoid in patients with:

  • Severe liver or kidney impairment

  • History of suicidal thoughts

  • Alcohol abuse (risk of liver injury with Duloxetine)

• Use with caution in:

  • Elderly patients (risk of falls, dizziness)

  • Those taking other CNS depressants or SSRIs

Monitor for:

• Mood changes

• Signs of serotonin syndrome (agitation, confusion, rapid heartbeat)

• Weight gain or edema (Pregabalin)

🤒 Side Effects

Common:

• Drowsiness, dizziness

• Dry mouth

• Nausea

• Weight gain

• Constipation

• Sweating

Serious:

• Suicidal ideation (especially in young adults)

• Liver dysfunction (from Duloxetine)

• Vision problems

• Serotonin syndrome (when combined with other serotonergic agents)

Seek medical help for symptoms like severe abdominal pain, jaundice, confusion, or chest pain.

🔄 Drug Interactions

• Avoid with:

  • MAO inhibitors (risk of serotonin syndrome)

  • CNS depressants (enhanced sedation)

  • Alcohol (increased liver risk)

• Dose adjustments may be needed with antihypertensives or antidiabetics

🧊 Storage Instructions

• Store at 15–30°C, in a dry, cool place

• Keep away from moisture, sunlight, and children

📝 Conclusion

Duloxetine 30mg + Pregabalin 75mg is a comprehensive solution for managing nerve pain, anxiety, and chronic discomfort, offering both pain suppression and mental relief. It addresses the neurological and psychological aspects of pain, helping patients regain mobility, comfort, and quality of life. With proper use and monitoring, it’s a powerful tool in modern neuropathic pain management.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult your healthcare provider for personalized recommendations.