Description

🌟 Overview

Ursodeoxycholic Acid (UDCA) 300mg is a bile acid used to treat various chronic liver and gallbladder diseases. It helps improve bile flow, reduce liver inflammation, and dissolve certain types of gallstones. It is especially beneficial for people with primary biliary cholangitis (PBC), certain cholestatic conditions, or gallstones not suitable for surgery.

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🧪 Ingredients & Mechanism of Action

• Active Ingredient: Ursodeoxycholic Acid 300 mg

• Inactive Ingredients: May include lactose monohydrate, microcrystalline cellulose, magnesium stearate, silica colloidal, and sodium starch glycolate (may vary by manufacturer).

How it Works:
UDCA replaces toxic bile acids, enhances bile flow, reduces cholesterol in bile, and protects liver cells from damage.

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✅ Indications / Uses

• Primary Biliary Cholangitis (PBC)

• Cholestatic Liver Diseases (including during pregnancy or cystic fibrosis)

• Dissolution of cholesterol gallstones (non-calcified, radiolucent)

• Prevention of gallstones in obese patients undergoing rapid weight loss or bariatric surgery

• Intrahepatic cholestasis of pregnancy (under supervision)

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📌 How to Use

• Dosage: Common adult dose is 10–15 mg/kg/day, typically in divided doses. A 70-kg adult may receive 1–2 tablets per day.

• Administration: Take with meals for better absorption and reduced gastrointestinal side effects.

• Do not crush or chew the tablet.

• Duration: May range from several months to lifelong, depending on the condition.

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⚠️ Common Side Effects

• Diarrhea or loose stools

• Nausea

• Abdominal discomfort

• Headache

• Back pain

• Dizziness

• Hair thinning (rare)

Most side effects are mild and temporary.

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🚨 Serious Side Effects (Seek Immediate Medical Attention)

• Worsening jaundice (yellowing of eyes/skin)

• Severe abdominal pain

• Signs of liver failure (dark urine, fatigue, confusion)

• Allergic reactions (rash, itching, swelling of face/lips, difficulty breathing)

• Severe diarrhea or dehydration

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🔍 Monitoring & Follow-Up

• Liver Function Tests (LFTs): Every 3–6 months to assess effectiveness

• Gallbladder Imaging (Ultrasound): If treating gallstones

• Renal and Hematologic Parameters: Periodically, especially in long-term use

• Clinical Assessment: Monitoring symptoms like itching, fatigue, or right upper quadrant pain

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⚠️ Warnings & Precautions

• Gallstone type: Only works for cholesterol-based stones, not calcified ones

• Pregnancy & Breastfeeding: Use only when benefits outweigh risks; often allowed in cholestasis of pregnancy

• Pediatric Use: Safe in select cases with medical supervision

• Liver Cirrhosis or Decompensation: Caution required

• Drug Interactions: Avoid aluminum-based antacids, cholestyramine, estrogens (reduce effectiveness)

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📝 Summary

Ursodeoxycholic Acid 300mg is a bile acid-based medication used for liver protection, gallstone dissolution, and improving bile flow in chronic cholestatic diseases. It is usually well tolerated, with mild gastrointestinal side effects being the most common. Routine liver tests and monitoring are essential to ensure safety and treatment efficacy. When used correctly, it plays a key role in managing complex liver and biliary disorders.

Always consult your doctor before starting or adjusting dosage.

Always consult a hepatologist or gastroenterologist before starting or stopping this medication.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.