VIDAVEL M 500 TABLET

🩸💊⚖️ Metformin 500mg + Vildagliptin 50mg Tablet: Dual-Action Control for Type 2 Diabetes

Metformin 500mg + Vildagliptin 50mg is a fixed-dose oral antidiabetic combination used in the management of Type 2 Diabetes Mellitus (T2DM). It brings together two complementary agents—Metformin, an insulin sensitizer, and Vildagliptin, a DPP-4 inhibitor—to effectively control blood glucose levels without causing significant weight gain or hypoglycemia. This combination is especially useful when monotherapy fails to maintain adequate glycemic control.

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🔬 Mechanism of Action

This tablet works through two distinct but synergistic mechanisms:

🔹 Metformin (500mg) – Biguanide class

• Reduces hepatic glucose production (gluconeogenesis)

• Increases peripheral glucose uptake in muscle cells

• Enhances insulin sensitivity

• Does not cause hypoglycemia when used alone

• Also helps in weight control

🔹 Vildagliptin (50mg) – DPP-4 Inhibitor

• Inhibits Dipeptidyl Peptidase-4 enzyme, thereby increasing levels of incretin hormones (GLP-1 and GIP)

• Enhances insulin secretion in response to meals

• Suppresses glucagon release during hyperglycemia

• Promotes glucose-dependent regulation, reducing the risk of hypoglycemia

Together, they offer comprehensive glycemic control by addressing both fasting and postprandial blood glucose levels.

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📌 Indications and Uses

• Type 2 Diabetes Mellitus (T2DM) in adults

• Used when:

  • Metformin alone is insufficient

  • Dual therapy is required at diagnosis

  • As part of combination regimens with insulin or other agents

It improves HbA1c levels, reduces the risk of diabetes-related complications, and helps achieve long-term glycemic targets.

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💊 Dosage and Administration

• Usual dose: One tablet twice daily, after meals

• Dose may be adjusted based on:

  • Kidney function

  • Response to therapy

• Should be taken with food to reduce gastrointestinal side effects from metformin

• Must not be crushed or chewed

Always follow your physician’s specific dosing instructions.

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⚠️ Precautions and Warnings

• Renal impairment: Use with caution or avoid if eGFR < 30 mL/min

• Risk of lactic acidosis with metformin—monitor for unexplained fatigue, muscle pain, or breathing difficulties

• Avoid excessive alcohol intake

• Discontinue temporarily before contrast imaging procedures

• Not for Type 1 diabetes or diabetic ketoacidosis

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🤒 Side Effects

Common:

• Nausea, vomiting

• Diarrhea

• Headache

• Dizziness

• Nasopharyngitis

Rare/Serious:

• Lactic acidosis (rare but serious)

• Pancreatitis (rare with DPP-4 inhibitors)

• Liver enzyme elevation

• Hypoglycemia (rare when used without sulfonylureas)

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🔄 Drug Interactions

• Cimetidine, alcohol, and radiologic contrast agents may increase metformin toxicity

• ACE inhibitors, diuretics, and NSAIDs may affect kidney function

• Risk of hypoglycemia increases when combined with sulfonylureas or insulin

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🧊 Storage Instructions

• Store at 15–25°C, away from moisture and direct sunlight

• Keep tightly closed and out of reach of children

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📝 Conclusion

Metformin 500mg + Vildagliptin 50mg provides a potent, well-balanced oral therapy for adults with Type 2 Diabetes, targeting multiple mechanisms of hyperglycemia. With a low risk of weight gain and hypoglycemia, this combination helps patients achieve better glycemic control, improve metabolic outcomes, and prevent long-term diabetic complications—making it a cornerstone in modern diabetes management.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.