XYGREL AS COMBOKIT

💊🛡️ Ticagrelor 90mg + Aspirin 75mg Tablet: Dual Antiplatelet Power for Heart Protection

The Ticagrelor 90mg + Aspirin 75mg combination tablet is a powerful dual antiplatelet therapy (DAPT) used to prevent heart attacks, strokes, and arterial thrombosis in patients with acute coronary syndrome (ACS) or those recovering from stent placement or a recent myocardial infarction (MI). This fixed-dose combination brings together two complementary antiplatelet agents: Ticagrelor, a reversible P2Y12 receptor antagonist, and Aspirin, a cyclooxygenase (COX) inhibitor. Together, they help inhibit platelet aggregation, thereby reducing the risk of life-threatening blood clots.

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🔬 Mechanism of Action

This tablet combines two antiplatelet mechanisms:

• Ticagrelor (90mg):
  A reversible P2Y12 receptor antagonist that inhibits ADP-induced platelet aggregation, reducing the ability of platelets to clump together and form clots. Ticagrelor works faster and more consistently than clopidogrel because it does not require metabolic activation.

• Aspirin (75mg):
  An irreversible inhibitor of COX-1, which blocks thromboxane A2—a potent promoter of platelet activation and vasoconstriction. Low-dose aspirin provides essential baseline platelet inhibition.

Together, they synergistically reduce the risk of clot formation in arteries already narrowed by atherosclerosis.

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📌 Indications and Uses

This fixed-dose combination is prescribed for:

• Acute Coronary Syndrome (ACS):

  • ST-elevation myocardial infarction (STEMI)

  • Non-STEMI (NSTEMI)

  • Unstable angina

• Secondary prevention of cardiovascular events in patients with:

  • Recent heart attack (up to 12 months post-MI)

  • Percutaneous coronary intervention (PCI) with stent placement

• Patients at high risk of thrombotic events

This therapy is usually part of the first-year post-MI treatment plan to prevent recurrence and improve survival.

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💊 Dosage and Administration

• Standard dose: One tablet containing Ticagrelor 90mg + Aspirin 75mg, twice daily

• Best taken with food to reduce gastrointestinal discomfort

• Should be continued as prescribed, usually for 12 months, unless advised otherwise

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⚠️ Precautions and Warnings

• Contraindications:

  • Active bleeding (e.g., peptic ulcer, intracranial hemorrhage)

  • History of hemorrhagic stroke

  • Severe liver impairment

  • Hypersensitivity to aspirin or Ticagrelor

• Use with caution in:

  • Asthma or COPD (Ticagrelor may cause dyspnea)

  • Bradycardia or AV block

  • Kidney or liver dysfunction

  • Patients on other blood thinners or NSAIDs

Regular monitoring of bleeding risk, hemoglobin, renal function, and cardiac status is recommended.

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🤒 Side Effects

Common:

• Bleeding (nosebleeds, gum bleeding, bruising)

• Shortness of breath (dyspnea)

• Indigestion or gastritis

• Headache

Serious:

• Major bleeding (GI, intracranial)

• Bradycardia or irregular heartbeat

• Allergic reactions (rash, swelling, breathing difficulty)

Seek immediate medical attention for black stools, vomiting blood, or unusual bleeding or fatigue.

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🔄 Drug Interactions

• Avoid with:

  • Strong CYP3A4 inhibitors/inducers (e.g., ketoconazole, rifampin)

  • Other anticoagulants or antiplatelets (increases bleeding risk)

• Avoid NSAIDs (further increases GI bleeding risk)

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🧊 Storage Instructions

• Store at room temperature (15–25°C)

• Protect from moisture and sunlight

• Keep out of reach of children

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📝 Conclusion

Ticagrelor 90mg + Aspirin 75mg tablet is a life-saving dual therapy that significantly reduces the risk of recurrence of heart attacks and strokes in high-risk cardiac patients. With its rapid onset and superior platelet inhibition, it forms the backbone of modern post-ACS treatment, offering proven benefits when taken regularly under physician guidance.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.