ZENOXA OD 150 TABLET

🧠💊 Oxcarbazepine 150mg Tablet: A Stabilizer for Nerve Impulses & Seizure Control

Oxcarbazepine 150mg is an anticonvulsant or antiepileptic medicine primarily prescribed to manage partial seizures in epilepsy. It may be used alone (monotherapy) or in combination with other antiepileptic drugs (adjunctive therapy). It works by stabilizing hyperexcited nerve cells in the brain and preventing the spread of seizure activity. Oxcarbazepine is a structural derivative of carbamazepine but has a better safety and tolerability profile.

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⚙️ Mechanism of Action

Oxcarbazepine acts by blocking voltage-sensitive sodium channels in neurons, reducing excessive nerve activity. This stabilizes overactive nerve membranes and suppresses the initiation and spread of abnormal electrical discharges in the brain that cause seizures.

It is a prodrug, converted in the liver to its active metabolite licarbazepine, which is responsible for its therapeutic effects.

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📋 Indications and Uses

Oxcarbazepine 150mg is indicated for:

• Partial seizures (with or without secondary generalization) in adults and children

• New-onset epilepsy

• Adjunctive therapy in patients not responding adequately to other antiepileptic drugs

• Occasionally used off-label for bipolar disorder or neuropathic pain, though not a primary indication

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💊 Dosage and Administration

• Typically initiated with 150mg once or twice daily, depending on age, weight, and seizure severity.

• Dose is gradually increased by the doctor to reach the target maintenance dose.

• Can be taken with or without food.

• For pediatric use, dosing is calculated based on weight.

⚠️ Never stop taking Oxcarbazepine abruptly; doing so may trigger seizures.

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⚠️ Precautions and Warnings

• Hypersensitivity reactions: Cross-reactivity may occur in patients allergic to carbamazepine.

• Hyponatremia (low sodium levels): Common, especially in elderly patients or those taking diuretics.

• Liver or kidney disease: Dosage adjustment may be required.

• May cause drowsiness and impair ability to drive or operate machinery.

• Caution in pregnancy – may cause birth defects; use only if clearly needed. Backup contraception is recommended as hormonal birth control effectiveness may be reduced.

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🤕 Side Effects

Common:

• Dizziness

• Drowsiness

• Fatigue

• Nausea

• Headache

• Double vision or blurred vision

Serious but rare:

• Hyponatremia (symptoms: confusion, seizures, fatigue)

• Skin rash, possibly severe (Stevens-Johnson Syndrome)

• Liver function abnormalities

• Suicidal thoughts or behavior (monitor mood closely)

Seek medical attention if you experience severe rash, confusion, allergic reaction, or unusual bleeding.

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🔄 Drug Interactions

• May decrease the effectiveness of oral contraceptives.

• Can interact with other antiepileptics like phenytoin, phenobarbital, and valproate.

• Enzyme-inducing drugs may affect oxcarbazepine metabolism.

Always inform your doctor about all medications or supplements being used.

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📦 Storage and Handling

• Store below 25°C in a dry place, away from light and moisture.

• Keep out of reach of children.

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📝 Conclusion

Oxcarbazepine 150mg tablet is a dependable and well-tolerated medication for managing partial seizures. It offers a safer alternative to older antiepileptics, with a reduced risk of serious side effects and fewer drug interactions. When taken as prescribed and monitored regularly, it plays a crucial role in controlling seizures, improving quality of life, and preventing seizure-related complications.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult your healthcare provider for personalized recommendations.