Overview:
Aceclofenac 100mg + Tizanidine 2mg is a combination medication commonly prescribed to relieve pain, inflammation, and muscle spasms. It combines Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), and Tizanidine, a muscle relaxant. This combination is especially used in conditions involving musculoskeletal pain, such as low back pain, cervical spondylosis, sciatica, and arthritis-related muscle stiffness.
How to Use:
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Dosage: Typically, one tablet is taken twice daily after meals or as directed by a physician.
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Route: Oral administration with a full glass of water.
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Duration: Use is generally short-term unless prescribed for chronic conditions.
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Note: Do not crush or chew the tablet; swallow it whole.
How Ingredients Work:
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Aceclofenac (100mg): Reduces pain and inflammation by inhibiting cyclooxygenase (COX) enzymes, which are involved in the synthesis of prostaglandins (chemicals that cause pain and inflammation).
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Tizanidine (2mg): Acts centrally on the spinal cord by stimulating alpha-2 adrenergic receptors, thereby inhibiting nerve signals that cause muscle spasms.
Common Side Effects:
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Gastrointestinal: Nausea, dyspepsia, abdominal pain, diarrhea
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Neurological: Drowsiness, dizziness, fatigue, dry mouth
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Others: Mild liver enzyme elevation, headache
These side effects are usually mild and self-limiting but should be reported if persistent.
Serious Side Effects:
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Liver Toxicity: Jaundice, dark urine, upper right abdominal pain—requires immediate medical attention
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Kidney Dysfunction: Swelling, decreased urine output, high blood pressure
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Allergic Reactions: Rash, itching, swelling of face/tongue, difficulty breathing (rare)
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Cardiovascular Risks: Increased risk of heart attack or stroke with long-term NSAID use
Discontinue use and seek emergency care if severe symptoms occur.
Monitoring and Follow-Up:
Patients on this combination, especially for extended periods, should be monitored through:
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Liver function tests (LFTs)
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Renal function tests (RFTs)
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Blood pressure monitoring
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Regular follow-ups to assess effectiveness and tolerance
Patients with a history of gastrointestinal ulcers or bleeding should undergo periodic gastrointestinal evaluations.
Warnings and Precautions:
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Contraindicated in: Patients with known hypersensitivity to NSAIDs or Tizanidine, active peptic ulcer, severe hepatic or renal impairment.
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Caution in: Elderly, hypertensive patients, or those on sedatives (Tizanidine can enhance CNS depression).
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Pregnancy & Lactation: Not recommended unless absolutely necessary and under physician supervision.
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Alcohol Use: Should be avoided due to increased risk of gastrointestinal bleeding and enhanced sedation.
Summary:
Aceclofenac 100mg + Tizanidine 2mg is a potent combination for managing pain, inflammation, and muscle spasm. It offers dual benefits: pain relief and muscle relaxation. While generally well tolerated, it requires careful use due to risks of liver damage, kidney issues, and cardiovascular events, especially with long-term use. Monitoring of liver and kidney function, blood pressure, and signs of gastrointestinal bleeding is critical. Patients should take it only under medical supervision, avoid alcohol, and adhere to the prescribed dose. When used responsibly, this combination can significantly improve quality of life in painful musculoskeletal disorders.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
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