ZORYL M4 TABLET

Description

Overview

Glimepiride 4mg + Metformin 500mg is a prescription oral antidiabetic medication used to treat type 2 diabetes mellitus. It is a fixed-dose combination of two well-established drugs—Glimepiride, a sulfonylurea, and Metformin, a biguanide. This dual therapy helps patients achieve better blood glucose control when a single medication (monotherapy) is not effective.

Composition

Each tablet contains:

• Glimepiride 4mg – stimulates the pancreas to release insulin

• Metformin 500mg – reduces glucose production in the liver and increases insulin sensitivity

This combination targets both insulin secretion and insulin resistance—two key factors in type 2 diabetes.

How It Works

• Glimepiride stimulates insulin secretion from pancreatic beta cells, helping lower blood glucose, especially after meals.

• Metformin reduces hepatic (liver) glucose production, decreases glucose absorption in the intestine, and enhances insulin sensitivity.

Together, these drugs work synergistically to control blood sugar levels more effectively than either drug alone.

Uses and Indications

This medication is prescribed for:

• Adults with type 2 diabetes who are not adequately controlled on metformin or glimepiride alone

• Patients requiring combination therapy for improved glycemic control

• Reducing the risk of long-term complications of diabetes, such as neuropathy, retinopathy, kidney disease, and cardiovascular issues

This medicine is not suitable for type 1 diabetes or for diabetic ketoacidosis.

How to Use

• Take once daily with a meal, preferably breakfast, to reduce the risk of gastrointestinal discomfort and low blood sugar.

• Swallow the tablet whole with water. Do not crush or chew.

• Follow your doctor’s instructions strictly regarding dosage and duration.

• Maintain a healthy diet and exercise regimen as recommended.

Possible Side Effects

Common:

• Hypoglycemia (low blood sugar) – symptoms include shakiness, dizziness, hunger, and sweating

• Nausea, vomiting, or diarrhea (commonly due to metformin)

• Weight gain (primarily due to glimepiride)

Serious:

• Lactic acidosis (rare) – symptoms include unusual tiredness, breathing difficulty, or stomach pain

• Allergic skin reactions – rash, itching, or hives

• Liver dysfunction – unusual fatigue, yellowing of the skin or eyes

Precautions

• Not recommended for patients with severe kidney or liver disease.

• Use caution in elderly patients and those with heart problems.

• Avoid alcohol, as it increases the risk of lactic acidosis and hypoglycemia.

• Not suitable during pregnancy or breastfeeding unless prescribed.

• Monitor blood sugar, renal function, and vitamin B12 levels regularly.

Conclusion

Glimepiride 4mg + Metformin 500mg is a proven, effective combination for the management of type 2 diabetes. It helps patients achieve better blood sugar control with a single tablet, improving adherence and reducing complications. However, it should be used with proper medical guidance and lifestyle modifications for the best outcomes.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.