AB-FLO N TABLET

🌬️💊 Acebrophylline 100mg + Acetylcysteine 600mg Capsule: Dual-Action Therapy for Respiratory Relief

The combination of Acebrophylline 100mg and Acetylcysteine 600mg in a single capsule offers a powerful and synergistic approach to managing chronic respiratory diseases, such as chronic bronchitis, chronic obstructive pulmonary disease (COPD), bronchial asthma, and emphysema. This fixed-dose combination works by reducing airway inflammation, dilating the bronchial passages, and thinning mucus, thereby making breathing easier and improving overall lung function.

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🔬 Mechanism of Action

This combination acts on multiple fronts to improve respiratory health:

🔹 Acebrophylline (100mg)

• A bronchodilator and mucoregulator derived from theophylline and ambroxol.

• Reduces inflammation in the airways by inhibiting phospholipase A2 and increasing cyclic AMP levels.

• Relaxes bronchial smooth muscles, improving airflow.

• Enhances mucociliary clearance, helping in removal of excess mucus.

🔹 Acetylcysteine (600mg)

• A mucolytic agent that breaks the disulfide bonds in mucus proteins, thinning thick, sticky mucus.

• Facilitates easy expulsion of mucus and improves oxygen exchange.

• Acts as a potent antioxidant by replenishing glutathione levels in the lungs, protecting tissues from oxidative stress.

Together, they address both obstruction and inflammation, offering symptomatic relief and long-term lung protection.

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📌 Indications and Uses

This capsule is indicated for the treatment and management of:

• Chronic Obstructive Pulmonary Disease (COPD)

• Chronic bronchitis

• Bronchial asthma (as adjunct therapy)

• Pulmonary fibrosis (adjunctive use)

• Cystic fibrosis

• Respiratory infections with excessive mucus production

It is especially useful in patients with productive cough, wheezing, and chest congestion.

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💊 Dosage and Administration

• Usual adult dose: One capsule once or twice daily, preferably after meals

• Swallow whole with water; do not crush or chew

• Duration of treatment depends on the severity and chronicity of the respiratory condition

Always follow the prescribing doctor’s instructions.

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⚠️ Precautions and Warnings

• Use with caution in:

  • Patients with peptic ulcers (Acetylcysteine may irritate gastric mucosa)

  • Liver or kidney dysfunction

  • Cardiac arrhythmias (due to Acebrophylline’s theophylline component)

• Not recommended for children unless prescribed

• Avoid alcohol and smoking, which worsen respiratory function

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🤒 Side Effects

Common side effects:

• Nausea

• Vomiting

• Stomach upset or heartburn

• Headache

• Mild dizziness

Rare but serious:

• Allergic reactions (rash, itching, swelling)

• Palpitations or irregular heartbeat

• Gastrointestinal bleeding (especially in those with ulcers)

Seek immediate medical help if you notice severe allergic symptoms or chest pain.

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🔄 Drug Interactions

• Use with caution with:

  • Other bronchodilators or xanthine derivatives

  • Antibiotics (may increase mucus clearance and absorption)

  • Antacids (may interfere with Acebrophylline metabolism)

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🧊 Storage Instructions

• Store in a cool, dry place below 25°C

• Keep away from moisture and direct sunlight

• Keep out of reach of children

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📝 Conclusion

The Acebrophylline 100mg + Acetylcysteine 600mg capsule provides a comprehensive dual-action treatment for respiratory conditions by opening airways, reducing inflammation, and clearing mucus. Ideal for chronic bronchitis and COPD patients, it enhances lung function, improves quality of life, and helps prevent respiratory exacerbations when used under proper medical guidance.