BROPHYLE CAPSULE

🌬️💊🫁 Acebrophylline 100mg Tablet: A Dual-Action Respiratory Aid for Easier Breathing

Acebrophylline 100mg is a mucolytic and bronchodilator medication widely used to treat respiratory conditions characterized by excessive mucus production, airway inflammation, and bronchospasm. It is especially effective in managing chronic obstructive pulmonary disease (COPD), bronchial asthma, chronic bronchitis, and emphysema. With both anti-inflammatory and mucus-thinning properties, Acebrophylline improves airflow and eases breathing, making it a valuable agent in chronic and acute respiratory therapy.

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🔬 Mechanism of Action

Acebrophylline is a unique compound combining two pharmacologically active components:

🔹 Ambroxol (a mucolytic)

• Enhances the production of pulmonary surfactant

• Breaks down and thins thick, sticky mucus in the airways

• Promotes mucociliary clearance, facilitating easier expectoration

🔹 Theophylline-7-acetic acid (a bronchodilator)

• Relaxes bronchial smooth muscle by inhibiting phosphodiesterase (PDE) enzymes

• Reduces bronchospasm and improves airflow

• Exhibits mild anti-inflammatory effects on the respiratory tract

Together, these actions help in clearing mucus and expanding the bronchial passages, providing symptomatic relief and improving lung function.

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📌 Indications and Uses

Acebrophylline 100mg is indicated in the treatment of:

• Chronic Obstructive Pulmonary Disease (COPD)

• Bronchial asthma

• Chronic bronchitis

• Emphysema

• Allergic bronchitis

• Acute exacerbations of chronic respiratory diseases

• Productive cough associated with thick mucus

It is usually part of maintenance therapy and often prescribed along with inhalers or corticosteroids.

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💊 Dosage and Administration

• Usual adult dose: 100mg once or twice daily, or as directed by a physician

• Should be taken after meals with a full glass of water

• Not recommended in children below 18 years unless advised by a doctor

• Dosage may be adjusted in patients with renal or hepatic impairment

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⚠️ Precautions and Warnings

• Use with caution in patients with:

  • Peptic ulcer

  • Severe liver or kidney disease

  • Cardiac arrhythmias

• Not suitable for acute bronchospasm; not a rescue medicine

• Avoid alcohol and smoking, as they can reduce the drug’s effectiveness

• Monitor for signs of theophylline toxicity in long-term use

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🤒 Side Effects

Common side effects:

• Nausea or vomiting

• Heartburn or gastric discomfort

• Dizziness or headache

• Dry mouth or mild cough

Rare but serious:

• Palpitations or irregular heartbeat

• Allergic reactions (rash, itching, swelling)

• Difficulty breathing or severe gastrointestinal upset

Discontinue use and seek medical advice if severe side effects occur.

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🔄 Drug Interactions

• May interact with:

  • Antibiotics like erythromycin or ciprofloxacin

  • Corticosteroids

  • Beta-blockers (may reduce effectiveness)

  • Other xanthine derivatives or stimulants

Regular monitoring is advised when taken with other long-term respiratory medications.

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🧊 Storage Instructions

• Store at room temperature (15–25°C)

• Protect from moisture and direct sunlight

• Keep out of reach of children

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📝 Conclusion

Acebrophylline 100mg tablet offers a dual-action approach for managing chronic respiratory conditions—combining mucolytic and bronchodilator effects in one formulation. It helps clear airways, reduce inflammation, and improve breathing in patients suffering from COPD, asthma, and bronchitis. When used consistently and under medical supervision, it significantly improves quality of life and lung function in individuals with chronic respiratory disease.