CLOPITAB A 150 CAPSULE

💊🛡️ Aspirin 150mg + Clopidogrel 75mg Tablet: Dual Antiplatelet Therapy for Heart & Stroke Protection

Aspirin 150mg + Clopidogrel 75mg is a fixed-dose combination used in dual antiplatelet therapy (DAPT) to prevent blood clot formation in individuals at high risk of cardiovascular events. This combination is commonly prescribed after a heart attack, stroke, or angioplasty with stent placement, helping to prevent thrombotic complications like myocardial infarction (MI), ischemic stroke, and peripheral artery disease.

By targeting two different pathways in platelet aggregation, the combination provides synergistic protection against clot formation while minimizing the risk of treatment failure due to single-agent resistance.

🔬 Mechanism of Action

🔹 Aspirin (150mg)

• Irreversibly inhibits cyclooxygenase-1 (COX-1) enzyme

• Blocks formation of thromboxane A2, a molecule that promotes platelet aggregation

• Provides antiplatelet, anti-inflammatory, and analgesic effects

• Effective at low doses for long-term cardiovascular protection

🔹 Clopidogrel (75mg)

• Prodrug converted in the liver to active form

• Irreversibly blocks the P2Y12 ADP receptor on platelets

• Inhibits platelet activation and aggregation

• Works synergistically with aspirin for enhanced antithrombotic effect

Together, these agents prevent the formation of blood clots in arteries, especially following vascular injury or stent placement.

📌 Indications and Uses

• Acute Coronary Syndrome (ACS): STEMI, NSTEMI, unstable angina

• Post-angioplasty (PCI) with stent placement

• Ischemic stroke or Transient Ischemic Attack (TIA) prevention

• Chronic stable angina and peripheral arterial disease (PAD)

• Post-coronary artery bypass graft (CABG)

💊 Dosage and Administration

• One tablet once daily, preferably with food

• Often used for 12 months after ACS or PCI, then continued with monotherapy (usually aspirin)

• Should be taken at the same time each day

⚠️ Precautions and Warnings

• Contraindicated in:

  • Active bleeding disorders (e.g., peptic ulcer, GI bleeding)

  • Hemorrhagic stroke

  • Severe liver disease

• Use with caution in:

  • Elderly patients (increased bleeding risk)

  • Patients with history of ulcers

  • Asthmatics (aspirin sensitivity)

  • Renal impairment

Regular monitoring may be needed for:

• Bleeding tendencies

• Hemoglobin/hematocrit levels

• Platelet count in long-term therapy

🤒 Side Effects

Common:

• Gastrointestinal discomfort

• Nausea, heartburn

• Mild bruising or bleeding (gums, nosebleeds)

Serious:

• Major bleeding (GI, intracranial)

• Allergic reactions

• Thrombocytopenia

• Aspirin-induced asthma or bronchospasm

Seek urgent care if you experience:

• Blood in stool or vomit

• Severe headache or confusion

• Unusual bleeding or bruising

🔄 Drug Interactions

• Increased bleeding risk with:

  • NSAIDs, anticoagulants (warfarin, heparin)

  • SSRIs, steroids

• Avoid proton pump inhibitors (PPIs) like omeprazole (may reduce clopidogrel effectiveness)

• Alcohol can enhance bleeding risk

🧊 Storage Instructions

• Store at room temperature (15–25°C)

• Keep in a dry place, away from sunlight and moisture

• Keep out of reach of children

📝 Conclusion

Aspirin 150mg + Clopidogrel 75mg tablet is a cornerstone therapy in modern cardiology, offering effective dual protection against arterial thrombosis in high-risk patients. Its ability to prevent heart attacks, strokes, and vascular events makes it a life-saving treatment when used under proper medical guidance, with close attention to bleeding risks and long-term monitoring.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.