Description
Dapagliflozin 10 mg is a prescription medication classified as a Sodium-Glucose Cotransporter-2 (SGLT2) inhibitor. It is primarily used to manage type 2 diabetes mellitus, chronic kidney disease (CKD), and heart failure. By inhibiting the SGLT2 protein in the kidneys, dapagliflozin prevents glucose reabsorption, leading to increased glucose excretion through urine and thereby lowering blood sugar levels.
 Indications
Dapagliflozin 10 mg is indicated for:
- Type 2 Diabetes Mellitus: Used alongside diet and exercise to improve blood sugar control.
- Chronic Kidney Disease (CKD): To reduce the risk of kidney function decline and related complications.​
- Heart Failure: To decrease hospitalization rates and improve survival in patients with heart failure.​
💊 Dosage and Administration
- Dosage: The typical dose is 10 mg once daily, taken with or without food. ​ Administration: Swallow the tablet whole with a glass of water.​
- Missed Dose: If a dose is missed, take it as soon as remembered unless it’s almost time for the next dose. Do not double the dose.​
âš Side Effects
Common side effects include:
- Genital Infections: Yeast infections in both men and women. ​
-  Urinary Tract Infections (UTIs): Symptoms may include burning sensation during urination, frequent urination, or cloudy urine.​
- Increased Urination: Due to osmotic diuresis.​
- Dehydration: May cause dizziness, lightheadedness, or fainting, especially when standing up
- Serious side effects (less common) include:
- Ketoacidosis: A serious condition where the body produces high levels of blood acids called ketones. ​
-  Kidney Problems: Signs include changes in urination or swelling in the legs.​
- Allergic Reactions: Such as rash, itching, or swelling of the face, lips, or throat.​
âš Precautions
- Kidney Function: Not recommended for patients with severe kidney impairment (eGFR <25 mL/min/1.73m²). ​
- Hypotension: Use with caution in patients with low blood pressure or those on diuretics.​
- Liver Disease: Monitor liver function during treatment.​
- Pregnancy and Breastfeeding: Consult a healthcare provider before use.​
🔄 Drug Interactions
- Diuretics: May increase the risk of dehydration and low blood pressure.​
- Insulin or Sulfonylureas: May increase the risk of low blood sugar; dose adjustments may be necessary.​
- ACE Inhibitors or ARBs: Monitor for kidney function and electrolytes.​
🧠Conclusion
Dapagliflozin 10 mg is an effective medication for managing type 2 diabetes, chronic kidney disease, and heart failure. Its mechanism of action, coupled with its benefits in weight loss and blood pressure reduction, makes it a valuable option in the treatment regimen. However, it is essential to use this medication under medical supervision, considering potential side effects and drug interactions. Regular monitoring and adherence to prescribed dosages are crucial for optimal outcomes.​
For more detailed information, consult your healthcare provider or refer to the official product literature.
