DURITE PLUS 10 TABLET

💧💊 Spironolactone 50mg + Torasemide 10mg Tablet: Dual-Action Diuretic for Effective Fluid and Blood Pressure Control

The Spironolactone 50mg + Torasemide 10mg tablet is a potent combination diuretic used for the treatment of edema (fluid retention) associated with heart failure, liver cirrhosis, kidney disorders, and hypertension. By combining a loop diuretic (Torasemide) with a potassium-sparing diuretic (Spironolactone), this medication offers enhanced fluid elimination while minimizing potassium loss—a common issue with conventional diuretics.

This fixed-dose combination is especially helpful in patients who require strong diuretic therapy but are at risk of electrolyte imbalance, particularly hypokalemia (low potassium).

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🔬 Mechanism of Action

This tablet combines two different diuretic mechanisms:

🔹 Torasemide 10mg – Loop Diuretic

• Acts on the loop of Henle in the kidney

• Inhibits the reabsorption of sodium, potassium, and chloride

• Produces potent diuresis (increased urine production)

• Helps to rapidly reduce fluid overload, swelling, and blood pressure

🔹 Spironolactone 50mg – Potassium-Sparing Diuretic / Aldosterone Antagonist

• Blocks aldosterone receptors in the distal tubules

• Promotes sodium and water excretion

• Retains potassium, preventing its loss in urine

• Provides cardioprotective effects by reducing myocardial fibrosis and remodeling

Together, they provide complementary benefits—Torasemide rapidly removes excess fluid, while Spironolactone ensures potassium is retained and aldosterone effects are blocked.

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📌 Indications and Uses

This combination is commonly used in the treatment of:

• Congestive Heart Failure (CHF)

• Hypertension (especially resistant cases)

• Ascites due to liver cirrhosis

• Nephrotic syndrome and chronic kidney disease (CKD)

• Edema due to various systemic conditions

• Secondary hyperaldosteronism

It helps improve symptoms of breathlessness, swelling, and high blood pressure, especially when single-agent diuretics fail to provide adequate relief.

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💊 Dosage and Administration

• Usual dose: One tablet once daily, preferably in the morning

• Take with food to minimize gastrointestinal side effects

• Dosage may be adjusted based on fluid status, blood pressure, kidney function, and serum electrolytes

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⚠️ Precautions and Warnings

• Regular monitoring of:

  • Serum potassium and sodium

  • Renal function (creatinine, BUN)

  • Blood pressure and fluid balance

• Use with caution in:

  • Elderly patients

  • Diabetics

  • Patients with renal insufficiency

• Contraindicated in:

  • Hyperkalemia

  • Severe kidney failure

  • Addison’s disease

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🤒 Side Effects

Common:

• Frequent urination

• Dizziness or hypotension

• Nausea

• Electrolyte disturbances

Serious:

• Hyperkalemia (muscle weakness, irregular heartbeat)

• Gynecomastia (with long-term Spironolactone use)

• Renal dysfunction

• Allergic reactions (rare)

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🔄 Drug Interactions

• Avoid with:

  • ACE inhibitors, ARBs, or potassium supplements (increased risk of hyperkalemia)

  • NSAIDs (may reduce diuretic effectiveness)

  • Lithium (increased toxicity risk)

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🧊 Storage Instructions

• Store at 15–25°C, in a cool, dry place

• Keep away from light and moisture

• Keep out of reach of children

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📝 Conclusion

Spironolactone 50mg + Torasemide 10mg is a powerful, synergistic diuretic combination ideal for patients with severe fluid overload and cardiac or renal comorbidities. Its potent diuretic effect, paired with potassium-sparing protection, ensures safer long-term therapy when closely monitored. A valuable option in advanced heart failure and resistant edema management, it offers both symptomatic relief and long-term benefit under proper medical supervision.

It is particularly useful in patients who require effective diuresis without the risk of severe potassium loss, a common problem with loop diuretics alone.

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🔬 Mechanism of Action

This combination works by targeting different parts of the nephron in the kidney:

🔹 Torasemide (10mg) – Loop Diuretic

• Acts on the ascending limb of the loop of Henle

• Inhibits sodium, chloride, and water reabsorption

• Results in potent and rapid diuresis

• Helps lower blood pressure and relieve edema

🔹 Spironolactone (25mg) – Aldosterone Antagonist

• Works on the distal convoluted tubule

• Blocks aldosterone, reducing sodium and water retention

• Preserves potassium, preventing hypokalemia

• Offers anti-fibrotic and cardioprotective benefits in heart failure patients

Together, they improve urine output, reduce swelling, and support cardiovascular function.

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📌 Indications and Uses

This combination is commonly prescribed for:

• Congestive Heart Failure (CHF)

• Chronic kidney disease (CKD) with fluid overload

• Cirrhotic edema and ascites

• Hypertension (especially resistant types)

• Nephrotic syndrome

• Patients requiring long-term diuretic therapy with potassium conservation

It is ideal for patients who need strong diuresis but are at risk of low potassium levels.

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💊 Dosage and Administration

• Typical adult dose: One tablet once daily, usually in the morning

• Should be taken with or after food to minimize gastric upset

• Dosage may be adjusted based on:

  • Fluid status

  • Blood pressure

  • Electrolyte levels

  • Kidney function

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⚠️ Precautions and Warnings

• Regular monitoring of:

  • Serum electrolytes (especially potassium and sodium)

  • Renal function

  • Blood pressure

• Avoid in:

  • Hyperkalemia

  • Addison’s disease

  • Severe renal insufficiency

• Caution in elderly, diabetics, and liver-impaired patients

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🤒 Side Effects

Common:

• Frequent urination

• Dizziness or low blood pressure

• Muscle cramps

• Fatigue

• Nausea

Less Common/Serious:

• Hyperkalemia (especially from Spironolactone)

• Gynecomastia or breast tenderness

• Electrolyte imbalance (if not monitored)

• Kidney dysfunction

Seek medical help if you experience irregular heartbeat, confusion, or muscle weakness.

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🔄 Drug Interactions

• Avoid with:

  • ACE inhibitors, ARBs, or potassium supplements – risk of hyperkalemia

  • NSAIDs – may reduce diuretic effect

• May enhance effects of other antihypertensives

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🧊 Storage Instructions

• Store below 25°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

Spironolactone 25mg + Torasemide 10mg is a well-balanced diuretic combination that offers strong fluid removal with potassium conservation. It is particularly suited for heart failure, kidney disease, and cirrhosis-related edema, where fluid overload and electrolyte management are critical. When used under proper medical supervision, it offers effective symptom relief and long-term cardiovascular support.