EBAMONT TABLET

🌼🤧💊 Ebastine 10mg + Montelukast 10mg Tablet: Dual-Action Relief for Allergies and Respiratory Comfort

Ebastine 10mg + Montelukast 10mg tablet is a powerful combination therapy used to treat allergic rhinitis, hay fever, and other allergy-related respiratory symptoms, including nasal congestion, sneezing, runny nose, and watery eyes. It is especially beneficial in individuals with seasonal or perennial allergies, or allergic symptoms associated with asthma, urticaria, or chronic rhinosinusitis. This combination brings together the benefits of two mechanisms: antihistamine activity (Ebastine) and leukotriene receptor blockade (Montelukast)—providing comprehensive symptom control.

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🔬 Mechanism of Action

This dual-action formula works synergistically:

🔹 Ebastine (10mg) – Second-generation antihistamine

• Selectively blocks H1 histamine receptors

• Reduces sneezing, itching, nasal discharge, and watery eyes

• Non-sedating due to poor penetration of the blood-brain barrier

• Long-acting (up to 24 hours), allowing once-daily dosing

🔹 Montelukast (10mg) – Leukotriene receptor antagonist (LTRA)

• Inhibits cysteinyl leukotriene receptors (CysLT1) in the lungs and nasal passages

• Decreases airway inflammation, bronchoconstriction, and mucus production

• Prevents symptoms triggered by allergens, pollution, or exercise

• Also used in mild asthma management

Together, they address both immediate histamine-driven symptoms and longer-lasting leukotriene-mediated inflammation, offering superior control over allergic conditions compared to monotherapy.

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📌 Indications and Uses

• Allergic rhinitis (seasonal & perennial)

• Pollinosis (hay fever)

• Chronic idiopathic urticaria

• Allergy-related asthma symptoms

• Sinusitis or nasal polyps with allergic features

• Exercise-induced bronchospasm (Montelukast component)

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💊 Dosage and Administration

• One tablet once daily, preferably in the evening or as prescribed

• Can be taken with or without food

• Should be used regularly during the allergy season or as part of chronic allergy management

• Not for acute asthma attacks

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⚠️ Precautions and Warnings

• Not suitable for children under 15 years unless prescribed in pediatric doses

• Use cautiously in:

  • Liver impairment

  • Neuropsychiatric history (rare behavioral effects with Montelukast)

• Avoid alcohol or other sedatives

• Not a substitute for rescue inhalers in asthma patients

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🤒 Side Effects

Common:

• Headache

• Dry mouth

• Drowsiness (less than older antihistamines)

• Stomach discomfort

Less common/serious:

• Mood changes, anxiety, agitation (Montelukast-related)

• Skin rash or allergic reactions

• Liver enzyme elevation (rare)

Discontinue and consult a doctor if severe mood changes, tremors, or skin reactions occur.

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🔄 Drug Interactions

• Ebastine may interact with antifungals and macrolide antibiotics (e.g., ketoconazole, erythromycin)

• Montelukast has minimal drug interactions but may be affected by enzyme inducers like rifampicin

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🧊 Storage Instructions

• Store at 15–25°C, in a dry place

• Keep away from moisture and direct sunlight

• Store out of reach of children

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📝 Conclusion

Ebastine 10mg + Montelukast 10mg tablet offers dual-pathway control of allergy symptoms, making it ideal for patients with persistent rhinitis, allergic asthma symptoms, or recurrent nasal allergies. It provides effective, long-lasting relief while maintaining a favorable safety and tolerability profile—ensuring comfort through all seasons of allergy.