ENZAMIDE 80 CAPSULE

🧬🛡️💊 Enzalutamide 80mg Tablet: Advanced Hormonal Therapy for Prostate Cancer Management

Enzalutamide 80mg is a second-generation androgen receptor inhibitor used in the treatment of prostate cancer, particularly metastatic castration-resistant prostate cancer (mCRPC) and non-metastatic castration-resistant prostate cancer (nmCRPC). It is a potent oral therapy designed to block the action of male hormones (androgens), including testosterone, which fuel the growth of prostate cancer cells.

Enzalutamide is prescribed to prolong survival, delay disease progression, and improve quality of life in men with advanced prostate cancer. It is often used alongside surgical or medical castration therapies (e.g., GnRH agonists).

🔬 Mechanism of Action

Enzalutamide works by competitively inhibiting androgen receptors on prostate cancer cells. Unlike older anti-androgens, it not only prevents testosterone binding but also:

• Inhibits nuclear translocation of the androgen-receptor complex

• Blocks DNA binding and coactivator recruitment

• Completely halts androgen-induced gene expression

This multi-targeted blockade stops the growth signals driven by androgens, thereby suppressing the progression of prostate cancer even in castration-resistant states.

📌 Indications and Uses

Enzalutamide 80mg is indicated for:

• Metastatic castration-resistant prostate cancer (mCRPC)

• Non-metastatic castration-resistant prostate cancer (nmCRPC)

• Metastatic castration-sensitive prostate cancer (mCSPC) – in combination with ADT (androgen deprivation therapy)

It is suitable for patients:

• With or without previous chemotherapy

• Who are progressing despite low testosterone levels

• As part of long-term cancer control strategy

💊 Dosage and Administration

• Standard adult dose: 160mg once daily (typically 2 tablets of 80mg) taken orally

• May be taken with or without food

• Should be taken at the same time each day

• ADT (surgical or medical castration) must be continued alongside Enzalutamide

Missed doses should be taken as soon as remembered unless it’s close to the next dose. Avoid doubling doses.

⚠️ Precautions and Warnings

• Seizure risk: Avoid in patients with history of seizures or conditions predisposing to seizures

• CNS effects: Dizziness, fatigue, and hallucinations can occur

• Monitor liver function and blood pressure

• Use with caution in patients with:

  • Cardiovascular disease

  • Renal or hepatic impairment

  • Cognitive decline

Contraindications:

• Pregnancy (category X – for male use only)

• Women and children

🤒 Side Effects

Common:

• Fatigue

• High blood pressure

• Hot flashes

• Weakness

• Back pain

• Diarrhea

• Joint pain

Serious/rare:

• Seizures

• Falls and fractures

• Cognitive changes

• Posterior reversible encephalopathy syndrome (PRES) – very rare

Regular follow-ups are essential to monitor side effects and treatment efficacy.

🔄 Drug Interactions

• Strong inducer of CYP3A4 and CYP2C19, may affect drugs like:

  • Warfarin

  • Omeprazole

  • Midazolam

• Avoid with strong CYP2C8 inhibitors (e.g., gemfibrozil)

Inform your doctor of all medications including herbal supplements.

🧊 Storage Instructions

• Store below 30°C, in original packaging

• Protect from moisture and light

• Keep out of reach of children

📝 Conclusion

Enzalutamide 80mg tablet is a next-generation androgen inhibitor that offers effective, long-term control of advanced prostate cancer, especially in cases resistant to conventional hormone therapy. Its ability to significantly delay disease progression, coupled with the convenience of oral administration, makes it a cornerstone in modern prostate cancer management. Proper monitoring ensures safety and maximizes therapeutic benefits.