Description
💊 Levofloxacin 250mg + Ornidazole 500mg Tablet – Dual Action Antibiotic Power
🔬 What is Levofloxacin + Ornidazole Tablet?
This combination tablet contains Levofloxacin 250mg (a broad-spectrum fluoroquinolone antibiotic) and Ornidazole 500mg (a nitroimidazole derivative with antiprotozoal and anaerobic antibacterial activity). It is prescribed to treat mixed infections involving both aerobic and anaerobic bacteria, as well as protozoa.
Together, they deliver synergistic action:
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Levofloxacin blocks bacterial DNA replication by inhibiting DNA gyrase.
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Ornidazole disrupts DNA synthesis in anaerobic organisms and protozoa.
✅ Uses / Indications
This combination is particularly effective in treating:
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Gastrointestinal infections (e.g., amoebiasis, giardiasis, dysentery)
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Pelvic inflammatory disease (PID)
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Dental infections and abscesses
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Post-surgical infections
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Gynecological infections
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Mixed respiratory or urinary infections with suspected anaerobic involvement
It is often prescribed where both bacterial and protozoal pathogens are suspected.
🧪 Composition / Ingredients
Each film-coated tablet contains:
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Levofloxacin Hemihydrate equivalent to 250mg of Levofloxacin
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Ornidazole 500mg
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Excipients: Microcrystalline cellulose, magnesium stearate, starch, PVP, coloring agents (varies by manufacturer)
⚠️ Precautions and Warnings
Before using this medication, consider the following:
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Allergy risk: Avoid if allergic to fluoroquinolones or nitroimidazoles.
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Seizure risk: Both components may lower seizure threshold; caution in epileptics.
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Tendon rupture warning: Especially in the elderly and those on corticosteroids.
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Hepatic impairment: Ornidazole is metabolized in the liver—monitor liver function.
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CNS effects: Dizziness, tremors, and confusion may occur.
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Pregnancy/Breastfeeding: Not recommended unless clearly necessary.
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Alcohol avoidance: Ornidazole may cause disulfiram-like reaction—avoid alcohol during and up to 48 hours after treatment.
💥 Side Effects
Common:
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Nausea
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Metallic taste
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Headache
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Dizziness
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Abdominal cramps
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Diarrhea
Rare but Serious:
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Tendonitis or tendon rupture
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Peripheral neuropathy
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Liver enzyme elevation
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Allergic reactions (rashes, swelling, anaphylaxis)
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Blood disorders (e.g., leukopenia)
Note: Discontinue and seek medical help if serious side effects occur.
📋 Dosage and Administration
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Typically, one tablet twice daily or as prescribed by a healthcare provider.
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Take with food to reduce stomach upset.
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Complete the full course, even if symptoms improve early.
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Avoid antacids, iron, and dairy near the time of dosing due to absorption interference.
🔄 Drug Interactions
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Alcohol: Can cause severe nausea and vomiting with Ornidazole.
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Anticoagulants (e.g., warfarin): Increased bleeding risk.
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Antiepileptic drugs: Increased seizure risk.
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CYP450 inhibitors may affect Ornidazole metabolism.
Always inform your doctor of all medications and supplements being taken.
📌 Conclusion
Levofloxacin 250mg + Ornidazole 500mg tablet is a potent combination therapy for polymicrobial infections involving both bacteria and protozoa. It is especially useful in gastrointestinal, dental, and gynecological infections. While effective, it must be taken with medical supervision due to possible adverse effects.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
