GLENZA 40 CAPSULE

🧬🛡️💊 Enzalutamide 40mg Tablet: Advanced Hormonal Therapy for Prostate Cancer

Enzalutamide 40mg is a potent androgen receptor inhibitor used in the treatment of prostate cancer, particularly in patients with metastatic castration-resistant prostate cancer (mCRPC), non-metastatic CRPC, and metastatic castration-sensitive prostate cancer (mCSPC). It works by blocking the effects of male hormones (androgens) like testosterone that fuel the growth of prostate cancer cells. Enzalutamide is an oral therapy that has significantly improved survival outcomes in advanced prostate cancer.

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🔬 Mechanism of Action

Enzalutamide is a second-generation androgen receptor (AR) inhibitor. It works on multiple levels to disrupt androgen signaling:

1. Prevents androgen binding to the androgen receptor

2. Blocks androgen receptor translocation to the nucleus

3. Inhibits AR-DNA binding and transcription of androgen-responsive genes

This triple-action mechanism effectively halts cancer cell proliferation and induces apoptosis (cell death), even in cancers that have become resistant to conventional androgen deprivation therapy (ADT).

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📌 Indications and Uses

Enzalutamide 40mg is approved for:

• Metastatic castration-resistant prostate cancer (mCRPC)

• Non-metastatic CRPC (high risk of metastasis)

• Metastatic castration-sensitive prostate cancer (mCSPC)

It is used alone or in combination with surgical or chemical castration (LHRH analogs) to suppress androgen production and activity.

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💊 Dosage and Administration

• Standard adult dose: 160mg once daily (i.e., four 40mg tablets taken together)

• Can be taken with or without food

• Swallow tablets whole with water; do not chew or crush

• Continue ADT (e.g., with GnRH analogs) while on enzalutamide

• Dose adjustments may be required in patients with seizure risk or liver impairment

Treatment is continued until disease progression or unacceptable toxicity.

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⚠️ Precautions and Warnings

• Seizure risk: Use caution in patients with a history of seizures or conditions predisposing to seizures

• Hypertension and falls/fractures are reported with prolonged use

• Monitor for fatigue, cognitive impairment, and mental health changes

• May impair male fertility

• Women who are pregnant or may become pregnant should avoid contact with crushed or broken tablets due to potential fetal harm

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🤒 Side Effects

Common:

• Fatigue

• Hot flashes

• Hypertension

• Musculoskeletal pain

• Dizziness or falls

• Weight loss

Serious:

• Seizures

• Posterior reversible encephalopathy syndrome (PRES) (rare but serious brain disorder)

• Cardiovascular events in predisposed individuals

Regular monitoring of blood pressure, liver function, and mental status is advised.

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🔄 Drug Interactions

• Strong CYP3A4 inducer and inhibitor—can affect metabolism of many drugs

• Avoid co-administration with:

  • Warfarin

  • Midazolam

  • Certain anticonvulsants and antifungals

• May reduce effectiveness of hormonal contraceptives

Always provide a complete medication list to your doctor before starting therapy.

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🧊 Storage Instructions

• Store at 20–25°C (room temperature)

• Protect from light and moisture

• Keep out of reach of children and pets

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📝 Conclusion

Enzalutamide 40mg tablet is a highly effective oral therapy that has transformed the management of advanced prostate cancer by targeting androgen receptors directly. It offers prolonged survival, delayed disease progression, and improved quality of life for patients who have become resistant to traditional hormone therapies. When used with careful monitoring, it remains a vital tool in the modern prostate cancer treatment arsenal.