LINAPRIDE M 500 XR TABLET

💊 Metformin 500 mg + Linagliptin 5 mg Tablet: Dual-Action Diabetes Control

🔹 What is Metformin + Linagliptin Tablet?

This combination tablet contains:

• Metformin (500 mg): A biguanide that lowers blood sugar by reducing glucose production in the liver and improving insulin sensitivity.

• Linagliptin (5 mg): A DPP-4 inhibitor that increases insulin release and decreases glucagon levels in response to meals.

Together, they offer complementary actions to control blood glucose in adults with Type 2 Diabetes Mellitus (T2DM) when diet, exercise, and single-drug therapy are insufficient.

🧪 Ingredients

• Active Ingredients:

  • Metformin Hydrochloride 500 mg

  • Linagliptin 5 mg

• Inactive Ingredients (may vary by manufacturer):

  • Hypromellose

  • Magnesium stearate

  • Povidone

  • Lactose monohydrate

  • Cellulose derivatives

💡 How to Use

• Dosage: Typically one tablet once or twice daily with meals, depending on blood sugar levels and doctor’s recommendation.

• Administration: Swallow whole with water. Take with food to minimize gastrointestinal side effects from Metformin.

• Do Not skip meals or overdose; maintain a regular schedule.

⚠️ Common Side Effects

From Metformin:

• Nausea

• Diarrhea

• Bloating

• Metallic taste

From Linagliptin:

• Nasopharyngitis (cold symptoms)

• Headache

• Joint pain

These side effects are usually mild and improve with time or dose adjustment.

🚨 Serious Side Effects

Seek medical attention for:

• Lactic acidosis (rare but life-threatening): Symptoms include muscle pain, weakness, difficulty breathing, slow heartbeat, or dizziness (linked to Metformin).

• Pancreatitis: Severe abdominal pain, vomiting (associated with Linagliptin).

• Hypoglycemia: Especially if used with insulin or sulfonylureas.

• Allergic reactions: Rash, itching, or swelling (angioedema), particularly from Linagliptin.

🩺 Monitoring & Follow-Up

Regular follow-up is crucial for effectiveness and safety:

• Blood glucose and HbA1c: Every 3–6 months

• Kidney function (eGFR): At baseline and periodically (important due to Metformin’s renal clearance)

• Liver function tests

• Signs of pancreatitis or lactic acidosis

Patients should maintain a diabetes diary to track glucose levels, diet, and medication adherence.

⚠️ Warnings & Precautions

• Renal impairment: Metformin should be used cautiously or avoided if eGFR < 30 mL/min/1.73 m².

• Alcohol use: Increases risk of lactic acidosis; should be limited.

• Heart failure: Monitor closely; risk of fluid retention or worsening condition.

• Elderly patients: Increased risk of side effects due to decreased renal function.

• Pregnancy & Lactation: Use only if clearly needed and under strict supervision.

📝 Summary

Metformin 500 mg + Linagliptin 5 mg is an effective oral combination therapy for managing Type 2 Diabetes. It targets blood sugar through two mechanisms: improving insulin sensitivity and enhancing the body’s natural insulin response. While generally well-tolerated, this medication requires regular monitoring for kidney function, blood sugar, and potential side effects like lactic acidosis or pancreatitis. It should be taken with meals and as part of a comprehensive diabetes management plan that includes diet and lifestyle changes.

• For more detailed information, consult with your healthcare provider or refer to trusted medical resources.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.