MEFNIWEL P TABLET

💊 Overview

This tablet is a dual-action painkiller that combines the anti-inflammatory effects of diclofenac with the pain-relieving and fever-reducing properties of paracetamol. It is commonly prescribed for musculoskeletal pain, dental pain, joint inflammation, and fever with pain.

🧪 Ingredients & Mechanism of Action

1. Diclofenac Sodium (50 mg) – A non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation, swelling, and pain by inhibiting cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis.

2. Paracetamol (325 mg) – An analgesic and antipyretic that raises the pain threshold and reduces fever by acting on the hypothalamic heat-regulating center.

Combined Action:
This combination provides faster and more effective pain relief with reduced gastrointestinal side effects compared to diclofenac alone.

✅ Indications / Uses

• Headache, migraine

• Dental pain and post-dental surgery pain

• Joint pain: osteoarthritis, rheumatoid arthritis

• Muscular pain, sprains, and strains

• Menstrual cramps

• Back pain, sciatica

• Fever with body aches

📋 How to Use

• Typical Dose: 1 tablet two to three times daily, after food.

• Route: Oral, with a full glass of water.

• Duration: Use for short-term relief unless advised otherwise.

• Do not exceed the maximum daily dose of paracetamol (4,000 mg/day) or diclofenac.

⚠️ Common Side Effects

• Gastric discomfort or acidity

• Nausea or vomiting

• Headache

• Dizziness

• Drowsiness

• Indigestion or bloating

These side effects are generally mild and short-lived.

🚨 Serious Side Effects (Seek Immediate Help)

• Gastrointestinal bleeding (black stools, vomiting blood)

• Liver damage (yellowing of eyes/skin, dark urine, fatigue)

• Allergic reaction (rash, itching, swelling, difficulty breathing)

• Kidney dysfunction (reduced urine output, swelling in legs)

• Severe abdominal pain or persistent nausea

• High blood pressure or cardiac symptoms (rare, but possible with long-term use)

🔍 Monitoring & Follow-Up

• Liver Function Tests (LFTs): Recommended if used regularly

• Renal Function Tests (KFTs): In elderly or long-term users

• Blood Pressure Monitoring: If used long term, especially in hypertensive patients

• GI Monitoring: Watch for signs of ulcers or bleeding

⚠️ Warnings & Precautions

• Liver Disease: Use with caution; paracetamol is hepatotoxic in overdose

• Kidney Impairment: NSAIDs can worsen renal function

• Stomach Ulcers or GI Bleeding: Avoid or use under strict supervision

• Pregnancy & Breastfeeding: Avoid in late pregnancy; use only under medical advice

• Alcohol Use: Increases risk of liver damage — avoid

• Elderly Patients: Increased risk of GI and kidney side effects

• Drug Interactions: Avoid using with other NSAIDs, blood thinners, or other paracetamol-containing medications

📝 Summary

The Diclofenac 50mg + Paracetamol 325mg tablet is a widely used, fast-acting, and effective treatment for mild to moderate pain and inflammation. It offers the benefits of reduced swelling, relief from pain, and control of fever in a single dose. However, due to potential liver, kidney, and gastrointestinal risks, it should be used for short-term relief under medical supervision. Regular monitoring is essential for safe long-term use.

Always follow your doctor’s dosage instructions and avoid self-medication.

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Here is a complete 500-word summary of Mefenamic Acid 500mg + Paracetamol 325mg tablet, including how it works, usage instructions, ingredients, side effects, monitoring, and precautions, with a clear headline and logo.

Mefenamic Acid 500mg + Paracetamol 325mg Tablet: Comprehensive Pain Relief Guide

Generic Name: Mefenamic Acid + Paracetamol
Strength: Mefenamic Acid 500mg + Paracetamol (Acetaminophen) 325mg
Drug Class: NSAID + Analgesic-Antipyretic
Form: Oral Tablet
Common Brand Names: Meftal-P, Mefkind-P, Flexon-M, P-Mefen

🌟 Overview

This combination tablet offers potent relief from pain, inflammation, and fever. It combines Mefenamic Acid, a strong NSAID for inflammation and cramps, with Paracetamol, a trusted pain and fever reliever. It is especially used in dysmenorrhea (menstrual pain), headache, muscle aches, toothache, and fever with body aches.

💊 Ingredients & Mechanism of Action

1. Mefenamic Acid (500 mg): A non-steroidal anti-inflammatory drug (NSAID) that blocks cyclooxygenase (COX) enzymes, reducing prostaglandin production to relieve inflammation and cramps.

2. Paracetamol (325 mg): Works on the brain’s pain and fever center, increasing pain threshold and reducing temperature.

Synergistic Effect:
This combination enhances pain relief while minimizing inflammation and reducing fever, with a relatively safer profile compared to stronger NSAIDs when used short-term.

✅ Indications / Uses

• Menstrual cramps (dysmenorrhea)

• Fever with body ache

• Headache and migraine

• Dental pain and post-extraction pain

• Muscular pain, backache

• Joint pain and mild arthritis

• Postoperative pain

📋 How to Use

• Dosage: Typically, 1 tablet two to three times daily after food, as prescribed.

• Route: Oral, with water.

• Do not take on an empty stomach to avoid gastric irritation.

• Duration: Short-term use only; not for continuous long-term treatment.

⚠️ Common Side Effects

• Nausea or vomiting

• Stomach discomfort or acidity

• Diarrhea or constipation

• Drowsiness

• Dizziness

• Mild skin rash

Usually mild and transient, especially when taken with food.

🚨 Serious Side Effects (Seek Medical Attention)

• Severe stomach pain or GI bleeding (black stools, blood in vomit)

• Liver toxicity (yellowing of skin/eyes, dark urine)

• Allergic reaction (rash, itching, swelling, difficulty breathing)

• Kidney issues (swelling, decreased urine output)

• High blood pressure or heart issues (rare)

🔍 Monitoring & Follow-Up

• Liver Function Tests (LFTs): Especially with long-term or high-dose use

• Renal Function Tests (KFTs): For prolonged use or in elderly patients

• GI Monitoring: Observe for any signs of ulcer or bleeding

• Hydration Status: Monitor in fever cases, especially in children or elderly

⚠️ Warnings & Precautions

• Liver disease: Paracetamol may worsen liver function

• Kidney disease: Use cautiously; mefenamic acid may affect kidney function

• Stomach ulcers/GI bleeding: Avoid in those with a history

• Pregnancy & Breastfeeding: Use only if clearly necessary and prescribed

• Alcohol: Avoid – increases liver toxicity risk

• Drug Interactions: Avoid with other NSAIDs, anticoagulants, or other paracetamol-containing medications

• Driving or Machinery: May cause drowsiness or dizziness — use caution

📝 Summary

The Mefenamic Acid 500mg + Paracetamol 325mg tablet offers effective and fast relief from pain, cramps, inflammation, and fever. It is especially favored for menstrual pain, muscle aches, and dental pain. While generally safe for short-term use, long-term or high-dose use requires close medical supervision due to potential risks to the stomach, liver, and kidneys.

Always follow your doctor’s advice, dosage instructions, and never self-medicate.