💊 Faropenem 200 mg + Clavulanic Acid 125 mg Tablet

Broad-Spectrum Antibiotic Combination – Product Overview

Overview

Faropenem 200 mg + Clavulanic Acid 125 mg is a fixed-dose oral antibiotic combination used to treat resistant bacterial infections. Faropenem is a penem-class beta-lactam antibiotic with broad-spectrum activity against Gram-positive, Gram-negative, and anaerobic bacteria. Clavulanic acid, a beta-lactamase inhibitor, prevents bacterial degradation of Faropenem, enhancing its effectiveness against resistant strains.

Common Brand Names: Farobact CV, Farozem CV, Clavopen
Form: Oral tablet
Prescription: Required
Indications:

• Respiratory tract infections (bronchitis, pneumonia)

• Skin and soft tissue infections

• Urinary tract infections

• Gynecological infections

• Intra-abdominal infections

Common Side Effects

These side effects are usually mild and self-limiting:

• Gastrointestinal: Nausea, vomiting, diarrhea, abdominal cramps

• Skin: Rash, itching, mild allergic reactions

• Neurological: Headache, dizziness

• Others: Metallic taste, flatulence

Serious Side Effects

Though rare, monitor for:

• Severe hypersensitivity reactions: Anaphylaxis, angioedema, difficulty breathing

• Clostridioides difficile-associated diarrhea: Persistent diarrhea, abdominal pain, or blood in stools

• Hepatic dysfunction: Jaundice, elevated liver enzymes, hepatotoxicity

• Seizures: Especially in patients with renal impairment or neurological disorders

• Hematologic abnormalities: Anemia, thrombocytopenia, leukopenia

Immediate medical attention is necessary if any of these occur.

Monitoring & Follow-Up

Monitoring is critical for early detection of adverse effects and ensuring therapeutic efficacy:

• Renal Function Tests: Creatinine, BUN — especially in elderly or renal-compromised patients

• Liver Function Tests: ALT, AST, bilirubin in long-term or high-dose therapy

• CBC: Periodically for detecting blood dyscrasias

• Therapeutic Response: Improvement within 48–72 hours; if not, consider culture and sensitivity testing

• Patient Education: Importance of full course adherence to prevent resistance

Warnings & Precautions

• Hypersensitivity: Contraindicated in patients allergic to beta-lactam antibiotics (penems, cephalosporins, penicillins)

• Renal Impairment: Dose adjustment may be required

• Hepatic Conditions: Monitor liver function; discontinue if liver injury is suspected

• Pregnancy & Lactation: Use only if clearly necessary; insufficient human data

• Pediatric Use: Use under strict medical supervision

• Drug Interactions: Use caution with probenecid (increases Faropenem levels) and valproic acid (risk of seizure)

Avoid unnecessary or prolonged use to reduce the risk of resistance development.

Summary

Faropenem 200 mg + Clavulanic Acid 125 mg is a powerful combination antibiotic designed to combat resistant bacterial infections. Faropenem offers broad-spectrum activity, while Clavulanic Acid enhances efficacy by inhibiting bacterial beta-lactamases. It is generally well tolerated, with most side effects being mild and gastrointestinal in nature. However, serious risks like allergic reactions, hepatotoxicity, and C. difficile infection exist, especially with misuse or prolonged therapy. Regular monitoring of liver, kidney, and hematologic parameters is advisable, particularly in vulnerable populations.

Always follow your doctor’s advice, dosage instructions, and never self-medicate.