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PEZOVER-SL CAPSULE

Levosulpiride 75mg + Pantoprazole 40mg

Leeford Healthcare Ltd

Description

Description

💊 Levosulpiride 75mg + Pantoprazole 40mg Capsule – Gut Relief, Inside Out


🔬 What is Levosulpiride + Pantoprazole Capsule?

This capsule is a combination of two gastrointestinal agents:

  • Levosulpiride 75mg: A prokinetic and antipsychotic belonging to the benzamide class. It works by enhancing gastrointestinal motility and increasing the release of acetylcholine in the enteric nervous system.

  • Pantoprazole 40mg: A proton pump inhibitor (PPI) that reduces stomach acid production by blocking the H+/K+ ATPase enzyme in the gastric lining.

Together, they offer a dual approach to treating acid-related and motility disorders of the upper gastrointestinal tract.


Uses / Indications

The Levosulpiride + Pantoprazole combination is primarily prescribed for:

  • Gastroesophageal Reflux Disease (GERD)

  • Functional dyspepsia

  • Non-ulcer dyspepsia

  • Irritable bowel syndrome with bloating

  • Heartburn with delayed gastric emptying

  • Acid peptic disorders

  • Nausea and bloating associated with poor gastric motility

It’s ideal when acid suppression alone is not sufficient, and motility dysfunction is suspected.


🧪 Composition / Ingredients

Each capsule typically contains:

  • Levosulpiride 75 mg (as sustained or immediate release)

  • Pantoprazole Sodium Sesquihydrate 40 mg (equivalent to Pantoprazole 40 mg as enteric-coated granules)

Excipients may include: cellulose derivatives, magnesium stearate, talc, and colorants, varying by brand.


⚠️ Precautions and Warnings

  • Neurological effects: Levosulpiride can cause extrapyramidal symptoms (tremors, restlessness, dystonia) with long-term use.

  • Mental health: Use with caution in patients with history of depression or psychosis.

  • Electrolyte imbalance: Long-term Pantoprazole use may cause hypomagnesemia or vitamin B12 deficiency.

  • Liver and kidney function: Use with caution in hepatic or renal impairment.

  • Pregnancy & Lactation: Should be used only if clearly needed under medical supervision.

  • Do not crush/chew: Swallow capsule whole for correct release of medication.


💥 Side Effects

Common:

  • Nausea

  • Diarrhea or constipation

  • Abdominal discomfort

  • Headache

  • Drowsiness or restlessness

Less Common / Serious:

  • Galactorrhea (milk discharge)

  • Gynecomastia (breast enlargement in males)

  • Tremors or involuntary movements

  • Mood swings, agitation

  • Low magnesium or B12 levels (with long-term Pantoprazole use)

Report any abnormal involuntary movements or breast-related changes immediately.


📋 Dosage and Administration

  • Typically 1 capsule daily, 30 minutes before breakfast.

  • Should be taken on an empty stomach for best absorption and effect.

  • Dosage duration depends on the condition and response to therapy.


🔄 Drug Interactions

  • Pantoprazole may reduce absorption of drugs needing acidic pH (e.g., ketoconazole, atazanavir).

  • Levosulpiride may interact with antipsychotics, levodopa, or sedatives.

  • Monitor if taking with antidepressants, diuretics, or digoxin.

Always inform your doctor about all medications and supplements you’re taking.


📌 Conclusion

The Levosulpiride 75mg + Pantoprazole 40mg capsule is a comprehensive solution for acid reflux and gastric motility disorders, especially effective when symptoms include bloating, nausea, and fullness. It combines acid suppression with prokinetic support, improving overall digestive comfort. However, long-term use should be monitored due to potential neurological and metabolic side effects.


Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.

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