PREGABID NT TABLET

🧠⚡💊 Pregabalin 75mg + Nortriptyline 10mg Tablet: Dual-Action Therapy for Nerve Pain and Mood Stabilization

Pregabalin 75mg + Nortriptyline 10mg is a combination medication used primarily for the treatment of neuropathic pain, which arises due to damaged or dysfunctional nerves. It is commonly prescribed in conditions like diabetic neuropathy, sciatica, postherpetic neuralgia, chronic back pain, and fibromyalgia. This dual-acting formula combines two powerful agents: Pregabalin, a gamma-aminobutyric acid (GABA) analog, and Nortriptyline, a tricyclic antidepressant (TCA), offering both pain relief and mood stabilization.

🔬 Mechanism of Action

🔹 Pregabalin 75mg

• Binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system

• Reduces the release of neurotransmitters like glutamate, noradrenaline, and substance P

• Decreases abnormal nerve signaling, thereby relieving pain and anxiety

🔹 Nortriptyline 10mg

• Inhibits reuptake of serotonin and norepinephrine, enhancing pain modulation in the spinal cord

• Modifies pain perception and helps relieve depression, anxiety, and sleep disturbances commonly associated with chronic pain

Together, they offer comprehensive relief from nerve pain and associated psychological symptoms, enhancing the quality of life in chronic pain sufferers.

📌 Indications and Uses

This combination is particularly effective in:

• Diabetic neuropathy

• Postherpetic neuralgia

• Peripheral nerve injury

• Fibromyalgia

• Sciatica or radiculopathy

• Chronic lower back pain with a neuropathic component

• Anxiety-related nerve pain

It also improves sleep quality, which is often impaired in chronic pain patients.

💊 Dosage and Administration

• Typical adult dose: One tablet once or twice daily, based on severity and physician’s advice

• Best taken at night to reduce daytime drowsiness

• Start low and titrate up gradually to improve tolerability

• Should be taken with or after food to minimize gastric side effects

⚠️ Precautions and Warnings

• Avoid alcohol and sedatives, as they can enhance drowsiness

• Use with caution in:

  • Elderly patients (increased fall risk)

  • Renal or hepatic impairment

  • Patients with heart rhythm disorders (due to Nortriptyline)

• May cause suicidal thoughts in rare cases—monitor mood changes

Not recommended during pregnancy or breastfeeding unless advised by a doctor.

🤒 Side Effects

Common:

• Drowsiness or sedation

• Dizziness, light-headedness

• Dry mouth

• Blurred vision

• Weight gain

• Constipation

Less common/serious:

• Mood changes (anxiety, agitation)

• Irregular heartbeat

• Urinary retention

• Allergic reaction (rash, swelling)

Report any severe or unusual symptoms to a doctor immediately.

🔄 Drug Interactions

• Increased sedation with:

  • Alcohol, benzodiazepines, opioids

• Caution with:

  • MAO inhibitors, SSRIs, beta-blockers, and other antidepressants

• Adjust dosage in renal impairment due to Pregabalin clearance

🧊 Storage Instructions

• Store in a cool, dry place (15–25°C)

• Keep away from direct sunlight and moisture

• Store out of reach of children and pets

📝 Conclusion

Pregabalin 75mg + Nortriptyline 10mg is a well-established, effective treatment for neuropathic pain conditions, offering both physical relief and psychological support. By targeting both nerve signals and mood imbalance, this combination improves pain control, sleep, and overall functioning, making it ideal for long-term management of chronic nerve-related disorders.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.