PREGAMET 75 CAPSULE

🧠🔥💊 Methylcobalamin 750mcg + Pregabalin 75mg Tablet: Nerve Pain Relief & Nerve Regeneration Combo

Methylcobalamin 750mcg + Pregabalin 75mg is a widely prescribed combination therapy used to treat neuropathic pain—a chronic pain condition resulting from nerve damage or dysfunction. This fixed-dose combination provides dual action: Pregabalin controls nerve pain signals, while Methylcobalamin (active vitamin B12) supports nerve regeneration and repair. Together, they offer enhanced relief for conditions like diabetic neuropathy, sciatica, herpes zoster-associated pain, and post-surgical nerve injuries.

🔬 Mechanism of Action

🔹 Pregabalin (75mg)

• A gamma-aminobutyric acid (GABA) analog, though it doesn’t act directly on GABA receptors.

• Binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system.

• Reduces calcium influx, thus decreasing the release of excitatory neurotransmitters (glutamate, substance P).

• Suppresses nerve hyperexcitability, thereby reducing neuropathic pain, burning sensations, and abnormal nerve signals.

🔹 Methylcobalamin (750mcg)

• A bioactive form of vitamin B12, essential for myelin sheath repair, neuronal health, and DNA synthesis.

• Enhances axonal regeneration, improves nerve conduction velocity, and helps reverse nerve degeneration.

• Especially important in diabetics and elderly, who are prone to B12 deficiency.

📌 Indications and Uses

This combination is highly effective in managing:

• Diabetic peripheral neuropathy

• Post-herpetic neuralgia (shingles-related pain)

• Trigeminal neuralgia

• Sciatica and radiculopathy

• Cervical and lumbar spondylosis with nerve compression

• Alcoholic neuropathy

• Chemotherapy-induced peripheral neuropathy

• Post-operative nerve pain or trauma-related nerve damage

💊 Dosage and Administration

• Usual adult dosage: One tablet once or twice daily, as directed by a physician

• Best taken after meals, with water

• Dose may be adjusted based on severity of symptoms, renal function, and individual tolerance

⚠️ Precautions and Warnings

• Pregabalin may cause drowsiness, dizziness, or blurred vision; avoid operating machinery or driving

• Use with caution in:

  • Kidney impairment (dose adjustment may be required)

  • History of substance abuse (Pregabalin has abuse potential)

  • Elderly patients prone to falls

• Methylcobalamin is usually safe, but prolonged high-dose use should be monitored

🤒 Side Effects

Common:

• Dizziness

• Sleepiness

• Dry mouth

• Weight gain

• Fatigue

Less common:

• Blurred vision

• Swelling of hands or feet

• Headache

• Gastrointestinal upset

Rare:

• Mood changes, confusion

• Allergic reactions (rash, itching, swelling)

Report any unusual symptoms like swelling, severe fatigue, or mood changes to your doctor.

🔄 Drug Interactions

• Avoid alcohol—it increases sedation

• Use with caution if taking:

  • CNS depressants (e.g., benzodiazepines, opioids)

  • Antidepressants or antiepileptic drugs

• Methylcobalamin may interact with chloramphenicol or proton pump inhibitors (PPIs) by reducing absorption

🧊 Storage Instructions

• Store below 25°C, in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children

📝 Conclusion

Methylcobalamin 750mcg + Pregabalin 75mg tablet is a synergistic and effective treatment for neuropathic pain, addressing both pain control and nerve healing. This combination enhances quality of life by reducing burning, tingling, and shooting pain, while supporting nerve recovery—a complete approach to long-term nerve health management.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.