CLAVAM BID DRY SYRUP

🌟 AMOXYCILLIN 125mg + CLAVULANIC ACID 31.25mg SYRUP: A COMPLETE OVERVIEW 🌟

Amoxycillin 125mg + Clavulanic Acid 31.25mg syrup is a widely prescribed pediatric antibiotic combination used to treat a range of bacterial infections. Formulated especially for children, this oral suspension combines Amoxycillin, a penicillin-class antibiotic, with Clavulanic Acid, a beta-lactamase inhibitor, enhancing its efficacy against resistant bacteria.

🔬 Composition and Mechanism of Action

• Amoxycillin (125mg/5ml): A broad-spectrum penicillin antibiotic that works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial death.

• Clavulanic Acid (31.25mg/5ml): A beta-lactamase inhibitor that prevents bacterial enzymes from deactivating amoxycillin, extending its activity against resistant strains.

This synergistic combination effectively targets both gram-positive and gram-negative bacteria, including strains that produce beta-lactamase enzymes which would otherwise neutralize penicillins.

💊 Indications and Uses

Amoxycillin + Clavulanic Acid syrup is commonly used to treat:

• Upper respiratory tract infections (e.g., sinusitis, tonsillitis, pharyngitis)

• Lower respiratory tract infections (e.g., bronchitis, pneumonia)

• Otitis media (middle ear infections)

• Skin and soft tissue infections

• Urinary tract infections (UTIs)

• Dental abscesses and infections

Its formulation is particularly tailored for pediatric use, with accurate dosing for infants and children based on weight and severity of infection.

⚠️ Precautions and Contraindications

Precautions:

• Ensure correct dosage by weight and age.

• Administer with food to reduce gastrointestinal upset.

• Complete the full course even if symptoms improve early.

• Shake the bottle well before each use.

Contraindications:

• Known allergy to penicillins, cephalosporins, or clavulanic acid.

• History of liver dysfunction or jaundice associated with this combination.

Caution is advised in children with kidney impairment, gastrointestinal diseases, or a history of allergic reactions.

🚨 Potential Side Effects

While generally well-tolerated, some children may experience side effects such as:

• Common: Diarrhea, nausea, vomiting, skin rash

• Less Common: Abdominal discomfort, headache

• Rare/Serious: Liver enzyme elevation, allergic reactions (rash, itching, swelling), Clostridium difficile-associated diarrhea, anaphylaxis

Seek medical attention for any signs of allergic reactions or persistent gastrointestinal symptoms.

🧊 Storage and Handling

• Store the reconstituted syrup in a refrigerator (2°C – 8°C) and use within 7–10 days.

• Discard unused portion after expiration.

• Keep out of reach of children and do not freeze.

📋 Additional Information

• Use only under the guidance of a pediatrician.

• Dosing should be strictly as per the physician’s instructions.

• Overuse or misuse may lead to antibiotic resistance.

Amoxycillin 125mg + Clavulanic Acid 31.25mg syrup remains a cornerstone in pediatric bacterial infection treatment, especially in cases of resistant organisms. Its proven safety profile and effectiveness make it a go-to choice in clinical practice—provided it is used judiciously and with appropriate monitoring.