SIBASTIN TABLET

🌸🤧💊 Ebastine 20mg Tablet: Long-Acting Antihistamine for Allergy Relief Without Drowsiness

Ebastine 20mg is a second-generation, non-sedating antihistamine used to treat a range of allergic conditions, such as allergic rhinitis, hay fever, urticaria (hives), and other skin or respiratory allergic responses. It works by blocking histamine H1 receptors, thus preventing allergic symptoms like sneezing, runny nose, itching, watery eyes, and rashes. Ebastine is preferred over first-generation antihistamines due to its minimal drowsiness and once-daily dosing.

The 20mg strength is typically used in moderate-to-severe allergic cases or when 10mg doses are insufficient.

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🔬 Mechanism of Action

Ebastine is a selective H1-receptor antagonist. After oral administration, it is rapidly converted in the liver to its active metabolite, carebastine, which effectively blocks the actions of histamine, a chemical released during allergic reactions.

Key actions:

• Reduces nasal and eye symptoms in allergic rhinitis

• Controls itching, redness, and swelling in urticaria

• Does not cross the blood–brain barrier easily, leading to minimal sedation

• Has a long duration of action (up to 24 hours)

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📌 Indications and Uses

Ebastine 20mg tablet is indicated for the relief of symptoms associated with:

• Seasonal allergic rhinitis (hay fever)

• Perennial allergic rhinitis

• Chronic idiopathic urticaria

• Skin allergies and dermatitis-related itching

• Food and drug-induced allergic reactions (as part of treatment)

Often used in patients who need full-day allergy control without sedation.

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💊 Dosage and Administration

• Adults and adolescents ≥12 years:
  Recommended dose is 20mg once daily, preferably at the same time each day.

• Can be taken with or without food.

• Swallow tablet whole with water.

• Not recommended for children under 12 years unless advised by a physician.

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⚠️ Precautions and Warnings

• Use with caution in patients with:

  • Liver disease

  • Cardiac conditions (e.g., QT prolongation risk)

• Avoid in:

  • Patients with known hypersensitivity to Ebastine

  • Pregnant or breastfeeding women unless prescribed

• Alcohol use may increase the risk of drowsiness (though rare)

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🤒 Side Effects

Common (mild and temporary):

• Headache

• Dry mouth

• Drowsiness (rare, mild)

• Fatigue

Rare but serious:

• Heart rhythm disturbances (QT prolongation, especially in high doses or with other QT-prolonging drugs)

• Skin rash or hypersensitivity reaction

Most side effects are mild and resolve on their own. If any severe reaction occurs (e.g., facial swelling, difficulty breathing), seek immediate medical attention.

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🔄 Drug Interactions

• Avoid with strong CYP3A4 inhibitors like ketoconazole, erythromycin, or clarithromycin, as they may raise Ebastine levels and increase side effect risk.

• Monitor if taken with other QT-prolonging drugs (e.g., amiodarone, quinolones).

• Can be safely combined with nasal sprays, decongestants, or inhaled corticosteroids in allergy treatment.

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🧊 Storage Instructions

• Store at 15–25°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

Ebastine 20mg tablet is a highly effective, long-lasting antihistamine for managing moderate to severe allergies. With its non-sedating profile, 24-hour relief, and excellent tolerability, it’s ideal for patients needing consistent control over allergic symptoms while maintaining daily activity and alertness.