ALDACTONE 50 TABLET

💧💊 Spironolactone 50mg Tablet: Balanced Diuretic for Heart, Hormones, and Hypertension

Spironolactone 50mg is a moderate-strength potassium-sparing diuretic and aldosterone antagonist widely used in the treatment of conditions involving fluid retention, hormonal imbalance, and hypertension. It works on the kidneys to remove excess sodium and water while conserving potassium, making it especially suitable for patients prone to electrolyte imbalances. Additionally, its anti-androgenic properties make it useful in hormone-related disorders like PCOS and acne.

🔬 Mechanism of Action

Spironolactone competes with aldosterone at receptors in the distal renal tubules, thereby:

• Increasing sodium and water excretion

• Retaining potassium

• Lowering blood volume and pressure

It also weakly blocks androgen receptors, making it useful in managing symptoms associated with excess male hormones, particularly in women.

This dual action allows it to address both cardiovascular and endocrine disorders, making it a versatile medication in modern medicine.

📌 Indications and Uses

Spironolactone 50mg is prescribed for:

🔹 Cardiovascular and Renal Conditions

• Edema (swelling) in:

  • Congestive heart failure

  • Liver cirrhosis with ascites

  • Nephrotic syndrome

• Hypertension (especially resistant types)

• Heart failure with reduced ejection fraction (HFrEF) – part of guideline-directed therapy

• Primary hyperaldosteronism (for diagnosis and treatment)

🔹 Hormonal and Dermatological Uses (off-label)

• Polycystic Ovary Syndrome (PCOS) – for hirsutism and acne

• Female pattern hair loss

• Hormonal acne

• Gynecomastia in men (occasionally used)

💊 Dosage and Administration

• Usual dose: 25–100mg/day depending on indication

• 50mg is commonly used as:

  • Maintenance dose for heart failure or hypertension

  • Moderate-dose therapy for hormonal conditions in women

• Can be taken once or twice daily, preferably with food to minimize stomach upset

Always follow your doctor’s dosage guidance. Blood tests to monitor potassium and kidney function are essential during treatment.

⚠️ Precautions and Warnings

• Hyperkalemia (high potassium) risk increases in:

  • Kidney disease

  • Elderly patients

  • Patients on ACE inhibitors, ARBs, or potassium supplements

• Use with caution in:

  • Diabetics

  • People with liver dysfunction

• Not recommended during pregnancy or breastfeeding

🤒 Side Effects

Common side effects:

• Nausea, upset stomach

• Headache, dizziness

• Breast tenderness or enlargement (gynecomastia)

• Menstrual irregularities

• Increased urination

Serious side effects:

• High potassium (muscle weakness, arrhythmias)

• Low sodium levels

• Kidney dysfunction

• Allergic reactions (rash, itching, swelling)

Seek immediate help for signs of electrolyte imbalance or severe allergic reactions.

🔄 Drug Interactions

• Risk of hyperkalemia with:

  • ACE inhibitors

  • ARBs

  • NSAIDs

  • Potassium supplements

• May interact with lithium and digoxin

Avoid potassium-rich foods or salt substitutes unless advised by a healthcare provider.

🧊 Storage Instructions

• Store at 15–30°C, in a dry, cool place

• Keep away from light, moisture, and children

📝 Conclusion

Spironolactone 50mg is a safe and effective therapy for managing a range of cardiovascular, renal, and hormonal conditions. Its potassium-sparing action and hormonal modulation make it a preferred option in sensitive patient groups. With proper dosing and regular monitoring, it can significantly improve both symptoms and quality of life.