TELVAS CT 40 TABLET

💊 Telmisartan 40mg + Chlorthalidone 12.5mg Tablet

Dual-Action Control for Blood Pressure and Cardiovascular Protection

Introduction:

The fixed-dose combination of Telmisartan 40mg and Chlorthalidone 12.5mg is a powerful once-daily antihypertensive therapy that offers synergistic blood pressure control. This medication merges two complementary mechanisms: Telmisartan, an angiotensin II receptor blocker (ARB), and Chlorthalidone, a long-acting thiazide-like diuretic. Together, they deliver enhanced efficacy, target organ protection, and improved cardiovascular outcomes, particularly in patients with moderate to severe hypertension or coexisting cardiovascular risks.

Pharmacological Action:

• Telmisartan 40mg blocks the angiotensin II receptor, preventing vasoconstriction and aldosterone release. This leads to:

  • Relaxation of blood vessels

  • Decreased sodium and water retention

  • Reduced blood pressure and improved cardiac output

• Chlorthalidone 12.5mg is a thiazide-like diuretic that acts on the distal renal tubules to:

  • Increase sodium and water excretion

  • Reduce plasma volume and vascular resistance

  • Lower blood pressure over 24 hours due to its long half-life

Therapeutic Indications:

• Essential hypertension (primary high blood pressure)

• Hypertension with risk of cardiovascular events (e.g., stroke, heart attack)

• Patients not controlled on monotherapy with either ARB or diuretic

• Hypertension in diabetics and those with chronic kidney disease (with caution and monitoring)

Dosage and Administration:

• One tablet once daily, preferably in the morning

• Can be taken with or without food

• Do not crush or chew the tablet

• Dose may be adjusted based on blood pressure response and renal function

• Avoid dehydration and excessive sun exposure due to diuretic content

Key Benefits:

• Superior blood pressure control through dual mechanisms

• Once-daily dosing improves patient adherence

• Telmisartan offers organ protection (heart, kidneys, and brain)

• Chlorthalidone provides long-lasting diuretic effect (24–72 hours)

• Reduces the risk of stroke, heart failure, and kidney disease progression

• Appropriate for patients who are non-responsive to single-agent therapy

Common Side Effects:

• Dizziness or lightheadedness (especially after the first dose)

• Increased urination (from Chlorthalidone)

• Muscle cramps or weakness

• Dry mouth or thirst

• Headache

Serious (But Rare) Side Effects:

• Electrolyte imbalances (low potassium, sodium)

• Elevated blood uric acid or glucose levels

• Kidney function changes

• Hypotension (especially in volume-depleted patients)

• Allergic reactions or rash

Precautions:

• Not to be used in pregnancy or breastfeeding

• Use with caution in patients with renal or hepatic impairment

• Regular monitoring of electrolytes, kidney function, and blood pressure is advised

• Avoid other potassium-sparing agents or supplements unless supervised

• Alcohol may enhance the blood pressure-lowering effect

Storage:

• Store in a cool, dry place at 15–30°C

• Protect from moisture and sunlight

• Keep out of reach of children

Conclusion:

Telmisartan 40mg + Chlorthalidone 12.5mg is an effective, well-tolerated combination therapy that provides robust 24-hour blood pressure control, protects against long-term organ damage, and simplifies treatment regimens. It’s an excellent choice for patients needing stronger blood pressure management with the added benefits of cardiovascular protection.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.