VILDAMBIC M TABLET

🩺🧬💊 Metformin 500mg + Vildagliptin 50mg Tablet: Dual-Action Power for Type 2 Diabetes Control

Metformin 500mg + Vildagliptin 50mg is a combination oral antidiabetic medication used to manage Type 2 Diabetes Mellitus (T2DM). It brings together two complementary agents—Metformin, a biguanide, and Vildagliptin, a DPP-4 inhibitor—to provide better glycemic control than either drug alone. This combination helps regulate both fasting and postprandial blood sugar levels, improve insulin sensitivity, and preserve pancreatic beta-cell function.

🔬 Mechanism of Action

🟢 Metformin (500mg)

• Reduces hepatic glucose production

• Enhances peripheral insulin sensitivity

• Decreases intestinal glucose absorption

• Does not cause hypoglycemia when used alone

• Promotes modest weight loss or weight neutrality

🔵 Vildagliptin (50mg)

• Inhibits dipeptidyl peptidase-4 (DPP-4)

• Increases levels of incretin hormones (GLP-1 and GIP)

• Enhances glucose-dependent insulin secretion

• Suppresses glucagon release after meals

• Has a low risk of hypoglycemia and is weight neutral

Together, this combination provides 24-hour glucose control, improving both HbA1c levels and day-to-day blood glucose variation.

📌 Indications and Uses

Metformin + Vildagliptin is prescribed for:

• Type 2 Diabetes Mellitus (T2DM) when:

  • Blood sugar is not controlled by metformin alone

  • Patient requires dual therapy from the outset

• Often part of a comprehensive diabetes care plan including diet and exercise

• Can be used as initial therapy in newly diagnosed T2DM with high HbA1c

💊 Dosage and Administration

• Standard dosage: One tablet twice daily, after meals

• Dosage may be modified based on:

  • Blood sugar levels

  • Kidney function (eGFR)

  • Tolerability

Do not crush or chew the tablet. Regular monitoring of blood glucose and HbA1c is essential.

⚠️ Precautions and Warnings

• Not for Type 1 diabetes or diabetic ketoacidosis (DKA)

• Renal function should be monitored regularly

• Caution in:

  • Elderly patients

  • Patients with heart failure or liver dysfunction

• Avoid alcohol (risk of lactic acidosis with metformin)

• Temporarily withhold in situations involving contrast dye or surgery

🤒 Side Effects

Common:

• Nausea, vomiting

• Diarrhea or abdominal discomfort (mainly from metformin)

• Headache

• Cold-like symptoms (vildagliptin)

Rare but serious:

• Lactic acidosis (metformin-related, rare but life-threatening)

• Liver enzyme elevation or rare hepatic dysfunction

• Pancreatitis (rare with DPP-4 inhibitors)

Seek medical attention for persistent vomiting, abdominal pain, unusual fatigue, or yellowing of the skin/eyes.

🔄 Drug Interactions

• Avoid with alcohol

• Monitor with drugs affecting kidney or liver function

• May be combined with other antidiabetics (e.g., insulin, sulfonylureas) under medical supervision

🧊 Storage Instructions

• Store at 15–25°C

• Protect from moisture and heat

• Keep out of reach of children

📝 Conclusion

Metformin 500mg + Vildagliptin 50mg is a trusted and effective combination therapy for people with Type 2 Diabetes, especially when lifestyle changes and monotherapy fall short. With a low risk of hypoglycemia, weight-neutral profile, and excellent glycemic control, it supports long-term diabetes management and helps reduce the risk of complications like heart disease, neuropathy, and kidney damage.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.