Description
💊 AMANTADINE 129 mg EXTENDED-RELEASE CAPSULE
Neurological Support with Sustained Relief
COMPOSITION:
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Amantadine Hydrochloride 129 mg
(Extended-release capsule for once-daily use)
WHAT IS AMANTADINE 129 mg?
Amantadine 129 mg is a centrally acting dopaminergic and NMDA receptor antagonist used primarily in the treatment of Parkinson’s disease and drug-induced extrapyramidal symptoms. This extended-release formulation is designed to maintain steady blood levels over a 24-hour period, enhancing convenience and tolerability.
It is also used to manage fatigue in multiple sclerosis (MS) and has been explored for off-label uses in various neurological disorders.
MECHANISM OF ACTION:
Amantadine’s therapeutic effect is derived from a dual mechanism:
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Dopaminergic Activity
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Promotes release of dopamine and inhibits its reuptake in the brain.
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Alleviates motor symptoms of Parkinsonism, including rigidity, tremor, and bradykinesia.
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NMDA Receptor Antagonism
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Blocks N-methyl-D-aspartate (NMDA) receptors, modulating excitatory glutamate transmission.
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Helps reduce dyskinesia and prevent neurotoxicity from excessive stimulation.
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INDICATIONS:
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Parkinson’s Disease (PD) – monotherapy in early stages or adjunct in advanced PD
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Drug-induced extrapyramidal symptoms (e.g., from antipsychotics)
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Fatigue in multiple sclerosis (MS) (off-label use)
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Post-viral fatigue syndromes (investigational use)
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Traumatic brain injury-related fatigue (off-label)
DOSAGE & ADMINISTRATION:
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Adults (extended-release formulation):
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129 mg once daily
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Dosage may be titrated based on clinical response and renal function
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For some indications, higher total daily doses (e.g., 258 mg) may be used in divided or adjusted formulations
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Capsules should be swallowed whole, not chewed or crushed.
Take at the same time each day, preferably in the morning to avoid insomnia.
KEY BENEFITS:
✅ Once-daily dosing for enhanced adherence
✅ Reduces motor symptoms and dyskinesia in Parkinson’s disease
✅ Improves fatigue and cognitive alertness in certain neurological conditions
✅ Offers an alternative to anticholinergics in drug-induced Parkinsonism
✅ Fewer peaks and troughs with extended-release formulation
PRECAUTIONS:
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Use cautiously in individuals with:
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Renal impairment
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Seizure disorders
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Congestive heart failure
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Psychiatric history (e.g., hallucinations, confusion)
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Gradual dose reduction is recommended when discontinuing therapy
POSSIBLE SIDE EFFECTS:
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Common: Dizziness, dry mouth, insomnia, nausea, constipation
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Occasional: Anxiety, blurred vision, edema, orthostatic hypotension
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Rare: Livedo reticularis (mottled skin discoloration), hallucinations, confusion, urinary retention
CONTRAINDICATIONS:
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Hypersensitivity to amantadine
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Untreated angle-closure glaucoma
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Severe renal insufficiency (without dose adjustment)
STORAGE INSTRUCTIONS:
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Store at room temperature (15–30°C)
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Keep in a dry place, protected from light
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Keep out of reach of children
DISCLAIMER:
This content is for educational purposes only. Always consult a licensed healthcare provider before starting or adjusting medication. Individualized dosing and monitoring are essential for safety and effectiveness.
